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• W2317703492 abstract "Event Abstract Back to Event Co-interaction between central oxytocin and corticotropin releasing hormone systems Valery Grinevich1* 1 German Cancer Research Center DKFZ and University of Heidelberg, Neuropeptides, Germany The hypothalamic neuropeptide oxytocin (OT) controls parturition and lactation in mammals and centrally orchestrates various types of social behaviors. In addition, OT exerts pronounced anxiolytic effects, which lead attenuation of stress and fear responses in mammalian species, including human. We recently gained genetic access to hypothalamic OT neurons in live rats by viral vectors to dissect the connectivity of OT neurons with various intra- and extrahypothalamic regions and exemplarily showed that optogenetic stimulation of local OT axons in the central nucleus of amygdala (CeA) – key brain regions controlling fear response – attenuates freezing behavior in fear-conditioned rats (Knobloch et al., 2012). Presently we are exploring an interaction of OT with the corticotropin-releasing hormone (CRH)- producing neurons, employing both viral-mediated cell-type specific targeting of CRH neurons and transgenic animal models, expressing genes of interest under the control of CRH promoter. As one of important finding obtained by now, we observed close oppositions of OT dendrites with CRH cell bodies in the hypothalamic paraventricular nucleus (PVN), which represents central limb of the hypothalamic-pituitary-adrenal (HPA) axis. The dissecting of mechanisms of co-interaction between two functionally opposing brain systems, such as OT and CRH systems, opens possibility to probe the dual neuropeptide control of stress response. Furthermore, advanced genetic approaches now allow studying the effects of neuropeptide release either from axons or dendrites in experimental models of anxiety, stress and fear. Acknowledgements This work was supported by the German Research Foundation (DFG) grants GR 3619/2-1, 3619/3-1, GR 3619/4-1 and Chica and Heinz Schaller Research Foundation References Knobloch, S., Charlet, A., Hoffmann, L.C., Eliava, M., Khrulev, S., Cetin, A.H., Osten, P., Schwarz, M. K., Seeburg, P.H., Stoop, R., Grinevich, V. (2012). Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron 73, 553-566. Keywords: Oxytocin, CRH, HPA axis, stress, viral vectors Conference: 4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Turkey, 30 Sep - 3 Oct, 2012. Presentation Type: Symposium Topic: Abstracts Citation: Grinevich V (2013). Co-interaction between central oxytocin and corticotropin releasing hormone systems . Conference Abstract: 4th Conference of the Mediterrarnean Neuroscience Society. doi: 10.3389/conf.fnhum.2013.210.00035 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Jan 2013; Published Online: 11 Apr 2013. * Correspondence: Dr. Valery Grinevich, German Cancer Research Center DKFZ and University of Heidelberg, Neuropeptides, Heidelberg, Germany, valery.grinevich@zi-mannheim.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Valery Grinevich Google Valery Grinevich Google Scholar Valery Grinevich PubMed Valery Grinevich Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2317703492 title "Co-interaction between central oxytocin and corticotropin releasing hormone systems" @default.
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