FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317713618> ?p ?o ?g. }

• W2317713618 endingPage "513" @default.
• W2317713618 startingPage "500" @default.
• W2317713618 abstract "Non-dioxin like polychlorinated biphenyls (NDL-PCBs) are legacy environmental contaminants with contemporary unintentional sources. NDL-PCBs interact with ryanodine receptors (RyRs), Ca(2+) channels of sarcoplasmic/endoplasmic reticulum (SR/ER) that regulate excitation-contraction coupling (ECC) and Ca(2+)-dependent cell signaling in muscle. Activities of 4 chiral congeners PCB91, 95, 132, and 149 and their respective 4- and 5-hydroxy (-OH) derivatives toward rabbit skeletal muscle ryanodine receptor (RyR1) are investigated using [(3)H]ryanodine binding and SR Ca(2+) flux analyses. Although 5-OH metabolites have comparable activity to their respective parent in both assays, 4-OH derivatives are unable to trigger Ca(2+) release from SR microsomes in the presence of Ca(2+)-ATPase activity. PCB95 and derivatives are investigated using single channel voltage-clamp and primary murine embryonic muscle cells (myotubes). Like PCB95, 5-OH-PCB95 quickly and persistently increases channel open probability (p o > .9) by stabilizing the full-open channel state, whereas 4-OH-PCB95 transiently enhances p o. Ca(2+) imaging of myotubes loaded with Fluo-4 show that acute exposure to PCB95 (5 µM) potentiates ECC and caffeine responses and partially depletes SR Ca(2+) stores. Exposure to 5-OH-PCB95 (5 µM) increases cytoplasmic Ca(2+), leading to rapid ECC failure in 50% of myotubes with the remainder retaining negligible responses. 4-OH-PCB95 neither increases baseline Ca(2+) nor causes ECC failure but depresses ECC and caffeine responses by 50%. With longer (3h) exposure to 300 nM PCB95, 5-OH-PCB95, or 4-OH-PCB95 decreases the number of ECC responsive myotubes by 22%, 81%, and 51% compared with control by depleting SR Ca(2+) and/or uncoupling ECC. NDL-PCBs and their 5-OH and 4-OH metabolites differentially influence RyR1 channel activity and ECC in embryonic skeletal muscle." @default.
• W2317713618 created "2016-06-24" @default.
• W2317713618 creator A5004348045 @default.
• W2317713618 creator A5024042726 @default.
• W2317713618 creator A5040431704 @default.
• W2317713618 creator A5050388265 @default.
• W2317713618 creator A5062413385 @default.
• W2317713618 creator A5066624530 @default.
• W2317713618 creator A5075285439 @default.
• W2317713618 creator A5079399944 @default.
• W2317713618 date "2013-09-07" @default.
• W2317713618 modified "2023-10-13" @default.
• W2317713618 title "Structure-Activity Relationship of Selected Meta- and Para-Hydroxylated Non–Dioxin Like Polychlorinated Biphenyls: From Single RyR1 Channels to Muscle Dysfunction" @default.
• W2317713618 cites W1749316807 @default.
• W2317713618 cites W1968308261 @default.
• W2317713618 cites W1971135976 @default.
• W2317713618 cites W1974917587 @default.
• W2317713618 cites W1982430817 @default.
• W2317713618 cites W1984031449 @default.
• W2317713618 cites W1989056964 @default.
• W2317713618 cites W1991042779 @default.
• W2317713618 cites W1998412465 @default.
• W2317713618 cites W2006474869 @default.
• W2317713618 cites W2006545372 @default.
• W2317713618 cites W2006872737 @default.
• W2317713618 cites W2010455912 @default.
• W2317713618 cites W2018628382 @default.
• W2317713618 cites W2018948218 @default.
• W2317713618 cites W2024117502 @default.
• W2317713618 cites W2026336678 @default.
• W2317713618 cites W2028203614 @default.
• W2317713618 cites W2031021430 @default.
• W2317713618 cites W2031821646 @default.
• W2317713618 cites W2035885166 @default.
• W2317713618 cites W2036359153 @default.
• W2317713618 cites W2041956619 @default.
• W2317713618 cites W2046668530 @default.
• W2317713618 cites W2047487564 @default.
• W2317713618 cites W2049580016 @default.
• W2317713618 cites W2054031641 @default.
• W2317713618 cites W2057153652 @default.
• W2317713618 cites W2059647854 @default.
• W2317713618 cites W2064583449 @default.
• W2317713618 cites W2067863141 @default.
• W2317713618 cites W2068315357 @default.
• W2317713618 cites W2069950229 @default.
• W2317713618 cites W2078360969 @default.
• W2317713618 cites W2078833625 @default.
• W2317713618 cites W2083271661 @default.
• W2317713618 cites W2087040379 @default.
• W2317713618 cites W2089943268 @default.
• W2317713618 cites W2097519636 @default.
• W2317713618 cites W2120111519 @default.
• W2317713618 cites W2122409052 @default.
• W2317713618 cites W2123388183 @default.
• W2317713618 cites W2123501956 @default.
• W2317713618 cites W2124458311 @default.
• W2317713618 cites W2127643065 @default.
• W2317713618 cites W2151289280 @default.
• W2317713618 cites W2161237133 @default.
• W2317713618 cites W2164824160 @default.
• W2317713618 cites W2171969201 @default.
• W2317713618 cites W2329935535 @default.
• W2317713618 doi "https://doi.org/10.1093/toxsci/kft202" @default.
• W2317713618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3858193" @default.
• W2317713618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24014653" @default.
• W2317713618 hasPublicationYear "2013" @default.
• W2317713618 type Work @default.
• W2317713618 sameAs 2317713618 @default.
• W2317713618 citedByCount "39" @default.
• W2317713618 countsByYear W23177136182014 @default.
• W2317713618 countsByYear W23177136182015 @default.
• W2317713618 countsByYear W23177136182016 @default.
• W2317713618 countsByYear W23177136182017 @default.
• W2317713618 countsByYear W23177136182018 @default.
• W2317713618 countsByYear W23177136182019 @default.
• W2317713618 countsByYear W23177136182020 @default.
• W2317713618 countsByYear W23177136182021 @default.
• W2317713618 countsByYear W23177136182022 @default.
• W2317713618 countsByYear W23177136182023 @default.
• W2317713618 crossrefType "journal-article" @default.
• W2317713618 hasAuthorship W2317713618A5004348045 @default.
• W2317713618 hasAuthorship W2317713618A5024042726 @default.
• W2317713618 hasAuthorship W2317713618A5040431704 @default.
• W2317713618 hasAuthorship W2317713618A5050388265 @default.
• W2317713618 hasAuthorship W2317713618A5062413385 @default.
• W2317713618 hasAuthorship W2317713618A5066624530 @default.
• W2317713618 hasAuthorship W2317713618A5075285439 @default.
• W2317713618 hasAuthorship W2317713618A5079399944 @default.
• W2317713618 hasBestOaLocation W23177136181 @default.
• W2317713618 hasConcept C113217602 @default.
• W2317713618 hasConcept C12554922 @default.
• W2317713618 hasConcept C126322002 @default.
• W2317713618 hasConcept C134018914 @default.
• W2317713618 hasConcept C158617107 @default.
• W2317713618 hasConcept C178790620 @default.
• W2317713618 hasConcept C181199279 @default.
• W2317713618 hasConcept C185592680 @default.

• next