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• W2317721878 abstract "Integrins represent a superfamily of cell surface molecules that are important mediators of cell-extracellular matrix interactions. Of the many known integrin subunit combinations, only a few (alpha 1 beta 1, alpha 2 beta 1, alpha 3 beta 1, alpha 6 beta 1, alpha 8 beta 1 and alpha v beta 3) appear to play significant roles in renal development and function. The current understanding of these roles is reviewed. Potential therapeutic benefits from the alteration of integrin function by arginine-glycine-aspartic acid peptides in renal ischemic injury have been suggested. Reduced tubular obstruction is a potential mechanism, however other mechanisms remain to be explored. Finally, recent studies suggest a mechanism whereby abnormal interactions between integrins and non-specifically glycosylated glomerular basement membrane components could be involved in the pathogenesis of diabetic nephropathy. The elucidation of other potential pathophysiological roles for integrins in renal disease has just begun." @default.
• W2317721878 created "2016-06-24" @default.
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• W2317721878 creator A5089761169 @default.
• W2317721878 date "1999-01-01" @default.
• W2317721878 modified "2023-10-15" @default.
• W2317721878 title "Integrins and the kidney: biology and pathobiology" @default.
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• W2317721878 doi "https://doi.org/10.1097/00041552-199901000-00003" @default.
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