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- W2317751926 abstract "It is generally considered that autophagy can selectively remove or isolate the damaged macromolecules and organelles, and even facilitate cells death. Such mechanism is to avoid these particles or cells disturbing normal cellular functions and physiology. The purposes of this study are to test the conditions that excess cadmium (Cd(superscript 2+)) and Zinc (Zn(superscript 2+)) induce autophagy. Based on the experimental data, we found that cadmium and zinc inhibit the growth of yeasts at 10μM and 5mM, respectively. Excess heavy metal actually induced autophagic protein expression and caused autophagosomes accumulated in the vacuole of protein-deficient yeast cells. Our results show that there are close connections between heavy metal toxicity and autophagy induction in the yeast. With further characterization of the molecular mechanisms of the autophagy and the cytoplasm to vacuole targeting pathways, it may help us to understand and handle the issues of heavy metal toxicity in higher organisms." @default.
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- W2317751926 date "2004-10-01" @default.
- W2317751926 modified "2023-09-23" @default.
- W2317751926 title "Cd(superscript 2+) and Zn(superscript 2+) Induce Autophagy in the Saccharomyces cerevisiae" @default.
- W2317751926 doi "https://doi.org/10.6576/azt.2004.14.(2).27" @default.
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