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• W2317814527 abstract "Our aim was to assess the pharmacokinetics of a low-dose schedule of paclitaxel in combination with radiation therapy in patients with brain tumors. Eighteen patients received 20–50 mg/m2 paclitaxel as a 1-h infusion 18–24 h before radiation with 2 Gy on 5 consecutive days. In total, 156 plasma samples from 13 patients and 38 urine samples from nine patients were collected and analyzed by a validated capillary electrophoresis method. Data analysis was done using NONMEM with a two-compartmental model and proportional error model. No signs of non-linearity in the pharmacokinetic parameters were observed in this dosing range. The median cumulative urinary excretion was 2.4% (range 0.86–7.72%) of the given dose. Plasma clearance was found to be 6.71 l/h±70% and central volume of distribution was 3.64 l±79% (population mean ± interindividual variability, respectively). At the time of the radiation, i.e. 24 h after administration with the lowest dose of 20 mg/m2, the mean concentration of paclitaxel was 0.038 mg/l (0.045 μM) in plasma. We conclude that even with the lowest dose of 20 mg/m2 paclitaxel, plasma concentrations at the time of radiation are achieved which are radiosensitizing in vitro." @default.
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• W2317814527 date "2003-07-01" @default.
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• W2317814527 title "Population pharmacokinetics of low-dose paclitaxel in patients with brain tumors" @default.
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• W2317814527 doi "https://doi.org/10.1097/00001813-200307000-00005" @default.
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