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- W2317860781 abstract "Glycogen is an important energy store of almost all living organisms. It is an alpha linked polymer comprised of thousands of glucose units. In bacteria it is usually synthesized when carbon ions are in excess in the growth medium and its synthesis helps for the survival of the bacteria under such nutritional conditions. Mycobacterium tuberculosis (M. tuberculosis), accumulates glycogen during the adverse condition such as reactive oxygen and nitrogen intermediates, low pH, nutrients and other vital element starvation for their survival in the host. Glycogen also plays a very important role in the pathogenesis of M. tuberculosis. The biosynthesis of glycogens is mediated by glycosyltransferases enzyme which can be divided into two families; glycogen transferase (GT) 3 and glycosyltransferases GT 5. Regulation of glycogen metabolism in bacteria involves a complex mechanism, involving several synthase enzymes such as glycogen synthase A (glgA), glycogen branching enzyme (glgB), and catalytic enzyme (glgC). Another enzyme known as glycogen phosphorylase (glgP), removes extra units of glucose from the non- reducing ends of the glycogen molecule. Several workers have recognized role of glycogen in Mycobacterial pathogenesis, in the recent years. Trehalose-dimycolate (TDM) and trehalose-monomycolate (TMM) present in the cell wall are indeed a precursor of mycolic acid of Mycobacteria, which plays an important role in its invasion and pathogenesis. This review focuses on various cycles and mechanisms involved in the glycogen synthesis in M. tuberculosis and its role in pathogenesis." @default.
- W2317860781 created "2016-06-24" @default.
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- W2317860781 date "2014-01-01" @default.
- W2317860781 modified "2023-09-23" @default.
- W2317860781 title "Glycogenomics of Mycobacterium tuberculosis" @default.
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- W2317860781 cites W1562537255 @default.
- W2317860781 cites W163727811 @default.
- W2317860781 cites W1642015145 @default.
- W2317860781 cites W1723797841 @default.
- W2317860781 cites W1796033386 @default.
- W2317860781 cites W1862479421 @default.
- W2317860781 cites W1967014582 @default.
- W2317860781 cites W1970677182 @default.
- W2317860781 cites W1971087365 @default.
- W2317860781 cites W1976757622 @default.
- W2317860781 cites W1980234998 @default.
- W2317860781 cites W1981320285 @default.
- W2317860781 cites W198363637 @default.
- W2317860781 cites W1987773708 @default.
- W2317860781 cites W1990740891 @default.
- W2317860781 cites W1992954716 @default.
- W2317860781 cites W199378738 @default.
- W2317860781 cites W1999147304 @default.
- W2317860781 cites W2008402427 @default.
- W2317860781 cites W2010331036 @default.
- W2317860781 cites W2014158957 @default.
- W2317860781 cites W2018021681 @default.
- W2317860781 cites W2018454041 @default.
- W2317860781 cites W2029296477 @default.
- W2317860781 cites W2033092971 @default.
- W2317860781 cites W2035651986 @default.
- W2317860781 cites W2037633136 @default.
- W2317860781 cites W2039044799 @default.
- W2317860781 cites W2043961099 @default.
- W2317860781 cites W2049905838 @default.
- W2317860781 cites W2052035473 @default.
- W2317860781 cites W2052565523 @default.
- W2317860781 cites W2056941858 @default.
- W2317860781 cites W2059115687 @default.
- W2317860781 cites W2063271557 @default.
- W2317860781 cites W2076021954 @default.
- W2317860781 cites W2076272357 @default.
- W2317860781 cites W2077098606 @default.
- W2317860781 cites W2082287966 @default.
- W2317860781 cites W2083190097 @default.
- W2317860781 cites W2083919147 @default.
- W2317860781 cites W2093071212 @default.
- W2317860781 cites W2095818547 @default.
- W2317860781 cites W2099529884 @default.
- W2317860781 cites W2099748948 @default.
- W2317860781 cites W2103035811 @default.
- W2317860781 cites W2103738707 @default.
- W2317860781 cites W2105935306 @default.
- W2317860781 cites W2114874948 @default.
- W2317860781 cites W2116269393 @default.
- W2317860781 cites W2118252112 @default.
- W2317860781 cites W2121105563 @default.
- W2317860781 cites W2124327251 @default.
- W2317860781 cites W2129319009 @default.
- W2317860781 cites W2130753366 @default.
- W2317860781 cites W2131705975 @default.
- W2317860781 cites W2132112146 @default.
- W2317860781 cites W2134276414 @default.
- W2317860781 cites W2137331382 @default.
- W2317860781 cites W2137762186 @default.
- W2317860781 cites W2141391869 @default.
- W2317860781 cites W2143024416 @default.
- W2317860781 cites W2144682353 @default.
- W2317860781 cites W2150463016 @default.
- W2317860781 cites W2151301735 @default.
- W2317860781 cites W2152190430 @default.
- W2317860781 cites W2156350829 @default.
- W2317860781 cites W2157800733 @default.
- W2317860781 cites W2159825609 @default.
- W2317860781 cites W2161266291 @default.
- W2317860781 cites W2164718888 @default.
- W2317860781 cites W2166374078 @default.
- W2317860781 cites W2169052801 @default.
- W2317860781 cites W2171222225 @default.
- W2317860781 cites W2319240686 @default.
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- W2317860781 doi "https://doi.org/10.4172/2161-1068.1000175" @default.
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