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- W2317861704 abstract "AIM: To compare the efficacy of lorazepam and chlordiazepoxide in alcohol withdrawal in an open label design. METHOD: The study sample consisted of 103 consecutive admissions to the de addiction ward, which after informed consent and selection based on inclusion criteria were randomised to two groups. A prospective inpatient analysis of withdrawal was done using CIWA-Ar and a comparison of the efficacy of chlordiazepoxide and lorazepam was done post randomization. Measurements the initial withdrawal assessment and subsequent progress of withdrawal was assessed using CIWA-Ar. The rate of withdrawal and total duration of withdrawal was compared among the two groups. RESULTS: Lorazepam treated group showed a significant difference in the rate of improvement over 48 hours compared to chlordiazepoxide group (71.3% vs. 57.4%; p=0.000). The total duration of withdrawal was also significantly lesser with lorazepam (5.7 vs. 6.9 days; p=0.001). A stepwise linear regression showed that 63% of the variance in improvement was related to the drug, thus proving the superiority of lorazepam. CONCLUSION: Lorazepam is more effective than chlordiazepoxide in alcohol withdrawal in both faster rate of fall of withdrawal severity and bringing down the total duration of withdrawal" @default.
- W2317861704 created "2016-06-24" @default.
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- W2317861704 date "2013-06-24" @default.
- W2317861704 modified "2023-09-26" @default.
- W2317861704 title "AN OPEN LABEL COMPARISON OF CHLORDIAZEPOXIDE AND LORAZEPAM IN ALCOHOL WITHDRAWAL" @default.
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- W2317861704 doi "https://doi.org/10.14260/jemds/886" @default.
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