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- W231788758 abstract "The effects on wound healing of chitosan and chitin wound dressings were clinically and histopathologically investigated using a split thickness wound in hairless dogs. Wound dressings used in this study included examined were dried porcine skin (DP skin), cotton type chitosan (CT chitosan) and chitin fiber dressing (chitin FD). Clinically, there were no differences in wound healing among the sites treated with chitosan, chitin and the untreated control sites. In contrast, DP skin and CT chitosan did not promote wound healing. CT chitosan dressings induced severe inflammatory reactions. In the sites treated with chitin FD, wound healing was delayed. Histopathologically, there were few differences in reepithelialization among the sites treated with chitosan, chitin and the WD-untreated sites. The sites treated with DP skin received elastic fibers from DP skin. CT chitosan dressings had a deleterious effect on wound healing (reepithelialization and granulation). Dyskeratosis, congestion, hemorrhage, cellular infiltration, intraand intercellular edema were seen in the epidermis. Bleeding, infiltration of inflammatory cells and mast cells, and edematous changes were seen in the dermis. In the sites treated with chitin FD, the invasion of mononuclear cells, mast cells and erythrocytes caused the retarded development of reepithelialization. It was concluded that chitosan and chitin had few deleterious effects on wound healing whereas DP skin, CT chitosan and chitin FD induced inflammation in the wound of hairless dogs. In addition, it was clear that there are species differences in the skin reactions to wound dressings. These results suggested special care should be taken in veterinary clinical use of human medical wound dressings." @default.
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- W231788758 date "2011-01-01" @default.
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- W231788758 title "The effects of chitosan and chitin wound dressings in hairless dogs." @default.
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