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• W2317961195 abstract "A progressive neurologic syndrome developed in six children with long-standing cholestatic liver disease. The neurologic abnormalities included areflexia, gait disturbance, decreased proprioceptive and vibratory sensation, and paresis of gaze. Serum vitamin E concentrations were uniformly low. Neuropathological studies carried out in two of the three fatal cases revealed degeneration of the posterior column, selective loss of large-caliber, myelinated axons in peripheral nerve, and spheroids in the gracile and cuneate nuclei. These lesions are similar to those found in animals with experimentally induced vitamin E deficiency. We therefore speculate that the neurologic syndrome in these children may be the result of chronic vitamin E malabsorption. (N Engl J Med. 1981; 304:503–8.)" @default.
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• W2317961195 date "1981-02-26" @default.
• W2317961195 modified "2023-09-25" @default.
• W2317961195 title "A Progressive Neurologic Syndrome in Children with Chronic Liver Disease" @default.
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• W2317961195 doi "https://doi.org/10.1056/nejm198102263040902" @default.
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