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- W2317990018 abstract "The WELCOME study prospectively evaluated the efficacy of certolizumab pegol (CZP) in patients with moderate to severe Crohn's disease (CD) who had previously responded to infliximab (IFX) but were no longer responding or had developed hypersensitivity. The aim of this analysis was to assess the influence of concomitant corticosteroids (CS) or immunosuppressants (IS) on response and remission rates to CZP in the WELCOME study. Patients (≥ 18 y) with a CD Activity Index (CDAI) score of 220-450 and a history of IFX failure (loss of response and/or hypersensitivity) were eligible for inclusion in WELCOME, a 26-week, multicenter trial consisting of 2 phases: (1) a 6-week open-label induction (CZP 400 mg at Weeks 0, 2, and 4); and (2) a double-blind maintenance phase (CZP 400 mg every 2 or 4 weeks). The primary endpoint was response rate (decrease in CDAI score ≥100 points [CDAI-100]) at Week 6. Secondary endpoints included CDAI-100 response rate and clinical remission (CDAI score of ≤150) at Week 26. Permitted concomitant medications at baseline included: CS at a stable dose for 2 weeks and IS (azathioprine, 6-mercaptopurine, and methotrexate) at a stable dose for 8 weeks prior to screening. CDAI-100 response was achieved by 62% of patients at Week 6. Remission was achieved in 39% of patients at Week 6 and in 30% of patients at Week 26. Baseline use of CS or IS had no impact on response or remission (Table) rates to CZP at Week 6 or Week 26. No caption available. No caption available. Induction and maintenance therapy with CZP was associated with consistent clinical remission in patients with moderate to severeCDwith secondary loss of response or hypersensitivity to IFX regardless of concomitant treatment with CS or IS." @default.
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- W2317990018 date "2009-12-01" @default.
- W2317990018 modified "2023-10-17" @default.
- W2317990018 title "Efficacy of certolizumab pegol in Crohnʼs disease patients with secondary failure to infliximab is not affected by concommittant medications" @default.
- W2317990018 doi "https://doi.org/10.1097/00054725-200912002-00043" @default.
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