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- W2317991311 abstract "High modulus, two-phase, bicontinuous scaffolds were prepared by photocross-linking an aqueous suspension of chondrocytes and N-methacrylate glycol chitosan with a hydrolyzable, hydrophobic, acrylated star-copolymer. Two acrylated star-copolymers were examined: poly(ε-caprolactone-co-d,l-lactide) (5446DLLACL) and poly(ε-caprolactone-co-trimethylene carbonate) (7030TMCCL). The scaffolds were assessed for injectability, two-phase interconnectivity, fatigue resistance, and long-term static culture behavior. The 7030TMCCL scaffolds demonstrated decreased moduli of 17% after 1 × 106 cycles at 30% strain and 5% after 56 days in culture, compared to the 5446DLLACL scaffolds, which exhibited decreases of 58 and 68%, respectively. The 7030TMCCL scaffolds accumulated more extracellular matrix after 56 days of culture (GAG: 20.1 ± 1, collagen: 35.5 ± 1.8 μg) compared to 5446DLLACL scaffolds (GAG: 13.2 ± 0.6, collagen: 6.2 ± 3.4 μg). Overall, the 7030TMCCL-based scaffolds were shown to be better suited for use as a load bearing soft tissue scaffold." @default.
- W2317991311 created "2016-06-24" @default.
- W2317991311 creator A5012207749 @default.
- W2317991311 creator A5062100501 @default.
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- W2317991311 date "2013-11-06" @default.
- W2317991311 modified "2023-09-25" @default.
- W2317991311 title "Injectable, High Modulus, And Fatigue Resistant Composite Scaffold for Load-Bearing Soft Tissue Regeneration" @default.
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- W2317991311 doi "https://doi.org/10.1021/bm4010595" @default.
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