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- W2317991808 abstract "Purpose: Colorectal cancers are the third most common type and second leading cause of cancer-related deaths in Western world. Histopathology is the gold standard method for diagnosis of colon cancers. To improve cancer diagnosis, ensure an effective treatment and better efficacy of treatment modalities, it is important to develop effective diagnostic method more reliable in terms of biochemical changes that can be detected in a cancerous tissue. To this end, we have developed spectral histopathology based on infrared (IR) imaging. The aims of this study are therefore to: (a) examine, using FTIR spectroscopy, the molecular changes between normal and tumoral colon tissues, (b) exploit the potentials of IR imaging to identify new diagnostic markers, and (c) develop an algorithm which could be applied in routine as a diagnostic tool directly and automatically on new unknown samples. Experimental procedure: IR imaging is a promising technique which has the potential to reveal intrinsic bio-molecular information in a tissue by probing vibrational motions of chemical bonds, thus giving a fingerprint of the composition and the structures. An IR imaging system (Spotlight 300, Perkin Elmer, Les Ulys, France) equipped with nitrogen-cooled 16-element MCT detector was calibrated to acquire images at 6.25 µm spatial and 4 cm −1 spectral resolutions averaged to 16 accumulations from 10µm thick sections of colon tissues placed on a calcium fluoride IR transparent window. These sections were embedded in paraffin block and stabilized in agarose matrix of a tissue micro array (TMA) slide consisting of 13 spots, each 3 mm in diameter. Adjacent 10 µm sections from the same TMA block were HE 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2741." @default.
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- W2317991808 date "2010-04-15" @default.
- W2317991808 modified "2023-09-24" @default.
- W2317991808 title "Abstract 2741: Spectral histopathology of paraffinised colon tissue microarrays: a new approach by infrared spectral imaging for colon cancer diagnosis" @default.
- W2317991808 doi "https://doi.org/10.1158/1538-7445.am10-2741" @default.
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