FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317993317> ?p ?o ?g. }

• W2317993317 endingPage "405" @default.
• W2317993317 startingPage "393" @default.
• W2317993317 abstract "The aim of this study was to examine the role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase (CPR) and determine the impact of this activation on increasing the activity especially with regard to multidrug resistant (MDR) tumour cells. It was found that at a high NADPH concentration (500 μmol/l), the anthracenedione agent ametantrone, with an unmodified quinone structure, was susceptible to CPR-dependent reductive activation. In contrast, it was shown that compounds with modified quinone grouping (benzoperimidine BP1, anthrapyridone CO1 and pyrazolopyrimidoacridine PPAC2) did not undergo reductive activation by CPR. This suggests that the presence of a modified quinone function is the structural factor excluding reductive activation of antitumour anthraquinone derivatives and analogues by CPR. In the second part of the work, the ability of antitumour anthraquinone derivatives and analogues to inhibit the growth of the human promyelocytic, sensitive leukaemia HL60 cell line as well as its MDR sublines exhibiting two different phenotypes of MDR related to the overexpression of P-glycoprotein (HL60/VINC) or MRP1 (HL60/DOX) was studied in the presence of exogenously added CPR. A significant increase in the activity of ametantrone with an unmodified quinone structure after its reductive conversion by CPR was observed against HL60 as well as HL60/VINC and HL60/DOX cells, whereas in the case of quinone-modified compounds (BP1, CO1 and PPAC2), the presence of the activation system had no effect on their activity against the sensitive and MDR tumour cells examined." @default.
• W2317993317 created "2016-06-24" @default.
• W2317993317 creator A5063849928 @default.
• W2317993317 creator A5069893577 @default.
• W2317993317 creator A5075553035 @default.
• W2317993317 creator A5082163720 @default.
• W2317993317 creator A5087375405 @default.
• W2317993317 date "2012-04-01" @default.
• W2317993317 modified "2023-09-25" @default.
• W2317993317 title "Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells" @default.
• W2317993317 cites W1494477800 @default.
• W2317993317 cites W1532556593 @default.
• W2317993317 cites W1976800730 @default.
• W2317993317 cites W1978333877 @default.
• W2317993317 cites W1999729424 @default.
• W2317993317 cites W2001204309 @default.
• W2317993317 cites W2013750836 @default.
• W2317993317 cites W2029063576 @default.
• W2317993317 cites W2036755280 @default.
• W2317993317 cites W2047221518 @default.
• W2317993317 cites W2051651085 @default.
• W2317993317 cites W2051804573 @default.
• W2317993317 cites W2054349513 @default.
• W2317993317 cites W2066207736 @default.
• W2317993317 cites W2068906133 @default.
• W2317993317 cites W2069273244 @default.
• W2317993317 cites W2069967580 @default.
• W2317993317 cites W2080036187 @default.
• W2317993317 cites W2089087952 @default.
• W2317993317 cites W2090942470 @default.
• W2317993317 cites W2093792954 @default.
• W2317993317 cites W2148365177 @default.
• W2317993317 cites W2158972216 @default.
• W2317993317 doi "https://doi.org/10.1097/cad.0b013e32834fcf4f" @default.
• W2317993317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22205152" @default.
• W2317993317 hasPublicationYear "2012" @default.
• W2317993317 type Work @default.
• W2317993317 sameAs 2317993317 @default.
• W2317993317 citedByCount "5" @default.
• W2317993317 countsByYear W23179933172013 @default.
• W2317993317 countsByYear W23179933172014 @default.
• W2317993317 countsByYear W23179933172016 @default.
• W2317993317 countsByYear W23179933172017 @default.
• W2317993317 countsByYear W23179933172020 @default.
• W2317993317 crossrefType "journal-article" @default.
• W2317993317 hasAuthorship W2317993317A5063849928 @default.
• W2317993317 hasAuthorship W2317993317A5069893577 @default.
• W2317993317 hasAuthorship W2317993317A5075553035 @default.
• W2317993317 hasAuthorship W2317993317A5082163720 @default.
• W2317993317 hasAuthorship W2317993317A5087375405 @default.
• W2317993317 hasConcept C134651460 @default.
• W2317993317 hasConcept C178790620 @default.
• W2317993317 hasConcept C181199279 @default.
• W2317993317 hasConcept C185592680 @default.
• W2317993317 hasConcept C190283241 @default.
• W2317993317 hasConcept C202751555 @default.
• W2317993317 hasConcept C2778903051 @default.
• W2317993317 hasConcept C2778913731 @default.
• W2317993317 hasConcept C2780643102 @default.
• W2317993317 hasConcept C29311851 @default.
• W2317993317 hasConcept C55493867 @default.
• W2317993317 hasConcept C71240020 @default.
• W2317993317 hasConceptScore W2317993317C134651460 @default.
• W2317993317 hasConceptScore W2317993317C178790620 @default.
• W2317993317 hasConceptScore W2317993317C181199279 @default.
• W2317993317 hasConceptScore W2317993317C185592680 @default.
• W2317993317 hasConceptScore W2317993317C190283241 @default.
• W2317993317 hasConceptScore W2317993317C202751555 @default.
• W2317993317 hasConceptScore W2317993317C2778903051 @default.
• W2317993317 hasConceptScore W2317993317C2778913731 @default.
• W2317993317 hasConceptScore W2317993317C2780643102 @default.
• W2317993317 hasConceptScore W2317993317C29311851 @default.
• W2317993317 hasConceptScore W2317993317C55493867 @default.
• W2317993317 hasConceptScore W2317993317C71240020 @default.
• W2317993317 hasIssue "4" @default.
• W2317993317 hasLocation W23179933171 @default.
• W2317993317 hasLocation W23179933172 @default.
• W2317993317 hasOpenAccess W2317993317 @default.
• W2317993317 hasPrimaryLocation W23179933171 @default.
• W2317993317 hasRelatedWork W1796599365 @default.
• W2317993317 hasRelatedWork W2003727722 @default.
• W2317993317 hasRelatedWork W2029644999 @default.
• W2317993317 hasRelatedWork W2045024644 @default.
• W2317993317 hasRelatedWork W2050822539 @default.
• W2317993317 hasRelatedWork W2089869974 @default.
• W2317993317 hasRelatedWork W2093331306 @default.
• W2317993317 hasRelatedWork W2181356712 @default.
• W2317993317 hasRelatedWork W2199584405 @default.
• W2317993317 hasRelatedWork W2317993317 @default.
• W2317993317 hasVolume "23" @default.
• W2317993317 isParatext "false" @default.
• W2317993317 isRetracted "false" @default.
• W2317993317 magId "2317993317" @default.
• W2317993317 workType "article" @default.