Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317997265> ?p ?o ?g. }
- W2317997265 endingPage "12" @default.
- W2317997265 startingPage "7" @default.
- W2317997265 abstract "The ability of human embryonic stem cells (hESCs) and their derivatives to differentiate and contribute to tissue repair has enormous potential to treat various debilitating diseases. However, improving the in vivo viability and function of the transplanted cells, a key determinant of translating cell-based therapies to the clinic, remains a daunting task. Here, we develop a hybrid biomaterial consisting of hyaluronic acid (HA) grafted with 6-aminocaproic acid moieties (HA-6ACA) to improve cell delivery and their subsequent in vivo function using skeletal muscle as a model system. Our findings show that the biomimetic material-assisted delivery of hESC-derived myogenic progenitor cells into cardiotoxin-injured skeletal muscles of NOD/SCID mice significantly promotes survival and engraftment of transplanted cells in a dose-dependent manner. The donor cells were found to contribute to the regeneration of damaged muscle fibers and to the satellite cell (muscle specific stem cells) compartment. Such biomimetic cell delivery vehicles that are cost-effective and easy-to-synthesize could play a key role in improving the outcomes of other stem cell-based therapies." @default.
- W2317997265 created "2016-06-24" @default.
- W2317997265 creator A5001640302 @default.
- W2317997265 creator A5001809317 @default.
- W2317997265 creator A5056856606 @default.
- W2317997265 creator A5073153977 @default.
- W2317997265 creator A5078374399 @default.
- W2317997265 creator A5084515376 @default.
- W2317997265 date "2014-12-01" @default.
- W2317997265 modified "2023-09-27" @default.
- W2317997265 title "Biomimetic Material-Assisted Delivery of Human Embryonic Stem Cell Derivatives for Enhanced In Vivo Survival and Engraftment" @default.
- W2317997265 cites W1485490516 @default.
- W2317997265 cites W1963566022 @default.
- W2317997265 cites W1968410373 @default.
- W2317997265 cites W1968814074 @default.
- W2317997265 cites W1969252837 @default.
- W2317997265 cites W1973403961 @default.
- W2317997265 cites W1974638778 @default.
- W2317997265 cites W1977784832 @default.
- W2317997265 cites W1978235057 @default.
- W2317997265 cites W1984253219 @default.
- W2317997265 cites W1985366897 @default.
- W2317997265 cites W1990897270 @default.
- W2317997265 cites W1995453479 @default.
- W2317997265 cites W2001315384 @default.
- W2317997265 cites W2001765087 @default.
- W2317997265 cites W2008346231 @default.
- W2317997265 cites W2019188119 @default.
- W2317997265 cites W2023748814 @default.
- W2317997265 cites W2034977295 @default.
- W2317997265 cites W2035847378 @default.
- W2317997265 cites W2043126651 @default.
- W2317997265 cites W2044461758 @default.
- W2317997265 cites W2045742275 @default.
- W2317997265 cites W2053328538 @default.
- W2317997265 cites W2060677662 @default.
- W2317997265 cites W2064395864 @default.
- W2317997265 cites W2067617639 @default.
- W2317997265 cites W2078220178 @default.
- W2317997265 cites W2081672340 @default.
- W2317997265 cites W2089753996 @default.
- W2317997265 cites W2090085208 @default.
- W2317997265 cites W2105577968 @default.
- W2317997265 cites W2110656344 @default.
- W2317997265 cites W2120703025 @default.
- W2317997265 cites W2123212221 @default.
- W2317997265 cites W2124326407 @default.
- W2317997265 cites W2130469852 @default.
- W2317997265 cites W2134110690 @default.
- W2317997265 cites W2145533255 @default.
- W2317997265 cites W2147968000 @default.
- W2317997265 cites W2163592912 @default.
- W2317997265 cites W2165220352 @default.
- W2317997265 cites W2177167308 @default.
- W2317997265 cites W2413780443 @default.
- W2317997265 doi "https://doi.org/10.1021/ab500021a" @default.
- W2317997265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4533864" @default.
- W2317997265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26280019" @default.
- W2317997265 hasPublicationYear "2014" @default.
- W2317997265 type Work @default.
- W2317997265 sameAs 2317997265 @default.
- W2317997265 citedByCount "16" @default.
- W2317997265 countsByYear W23179972652015 @default.
- W2317997265 countsByYear W23179972652016 @default.
- W2317997265 countsByYear W23179972652017 @default.
- W2317997265 countsByYear W23179972652018 @default.
- W2317997265 countsByYear W23179972652021 @default.
- W2317997265 countsByYear W23179972652022 @default.
- W2317997265 crossrefType "journal-article" @default.
- W2317997265 hasAuthorship W2317997265A5001640302 @default.
- W2317997265 hasAuthorship W2317997265A5001809317 @default.
- W2317997265 hasAuthorship W2317997265A5056856606 @default.
- W2317997265 hasAuthorship W2317997265A5073153977 @default.
- W2317997265 hasAuthorship W2317997265A5078374399 @default.
- W2317997265 hasAuthorship W2317997265A5084515376 @default.
- W2317997265 hasBestOaLocation W23179972652 @default.
- W2317997265 hasConcept C104317684 @default.
- W2317997265 hasConcept C10854531 @default.
- W2317997265 hasConcept C10882517 @default.
- W2317997265 hasConcept C136229726 @default.
- W2317997265 hasConcept C145103041 @default.
- W2317997265 hasConcept C1491633281 @default.
- W2317997265 hasConcept C150903083 @default.
- W2317997265 hasConcept C171056886 @default.
- W2317997265 hasConcept C198826908 @default.
- W2317997265 hasConcept C201750760 @default.
- W2317997265 hasConcept C207001950 @default.
- W2317997265 hasConcept C28328180 @default.
- W2317997265 hasConcept C49892992 @default.
- W2317997265 hasConcept C55493867 @default.
- W2317997265 hasConcept C71924100 @default.
- W2317997265 hasConcept C86803240 @default.
- W2317997265 hasConcept C95444343 @default.
- W2317997265 hasConceptScore W2317997265C104317684 @default.
- W2317997265 hasConceptScore W2317997265C10854531 @default.
- W2317997265 hasConceptScore W2317997265C10882517 @default.
- W2317997265 hasConceptScore W2317997265C136229726 @default.
- W2317997265 hasConceptScore W2317997265C145103041 @default.