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• W2318018169 abstract "Purpose: Recent studies have shown that normotensive subjects with electrocardiographically determined Left Ventricular Hypertrophy (ECG-LVH) are at risk of multiple cardiovascular diseases. However, the underlying mechanisms remain to be elucidated. In this study, we tested our hypothesis that normotensive individuals with ECG-LVH have reduced plasma levels of metabolites of Nitric Oxide (NO), a critical regulator of cardiovascular function. Methods: Among 579 Japanese male workers (40-65 years of age) without hypertension [antihypertensive treatment or blood pressure (BP) ≥140/90 mmHg], we finally studied 73 subjects with ECG-LVH and 292 subjects without ECG-LVH who were matched for age, and systolic and diastolic BP. ECG-LVH was determined by the Sokolow-Lyon voltage >38 mm and the Cornell voltage-duration product >2440 mm×ms. Plasma levels of NOx (NO metabolites, nitrite and nitrate) were measured by the Griess method. The subjects were categorized by quartiles of plasma NOx levels, and a logistic regression analysis was conducted relating the prevalence of ECG-LVH to NOx quartiles after adjusting age, waist circumference, and systolic and diastolic BP, and smoking status. Results: Of the clinical characteristics, the subjects with ECG-LVH had lower body mass index, waist circumference, serum triglyceride and fasting insulin levels and higher serum high-density lipoprotein cholesterol levels as compared with the subjects without ECG-LVH (each P<0.05). The median levels of plasma NOx were significantly reduced in the subjects with ECG-LVG as compared with the subjects without ECG-LVH [22.5 (IQR: 15.1-41.0) mmol/l vs. 36.8 (IQR: 25.0-56.2) mmol/l, P<0.05]. In the subgroup analysis, there also was a significant negative correlation between the prevalence rate of ECG-LVH and the NOx quartiles [39.6% in the first (<22.5 mmol/l, n=91), 15.2% in the second (22.5-33.4 mmol/l, n=92), 14.3% in the third (33.8-52.9 mmol/l, n=91), and 11.0% in the fourth quartile of NOx (52.9 mmol/l<, n=91), respectively, P<0.05]. The multivariate-adjusted odds ratio for the presence of ECG-LVH compared with the fourth quartile of NOx was 6.64 (95% CI: 2.98-16.11) (P<0.05) for the first, 1.56 (95% CI: 0.61-4.13) for the second, and 1.33 (95% CI: 0.54-3.34) for the third quartile of NOx. Conclusions: These results demonstrated for the first time that plasma NOx levels are markedly reduced in normotensive middle-aged men with ECG-LVH, indicating that disrupted NO production may explain, at least in part, the potential mechanism for increased cardiovascular risk in normotensive individuals with ECG-LVH." @default.
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• W2318018169 date "2013-08-02" @default.
• W2318018169 modified "2023-09-30" @default.
• W2318018169 title "Reduced plasma levels of nitric oxide metabolites in normotensive middle-aged men with electrocardiographically determined left ventricular hypertrophy" @default.
• W2318018169 doi "https://doi.org/10.1093/eurheartj/eht308.p1583" @default.
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