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• W2318041046 startingPage "17778" @default.
• W2318041046 abstract "In this study, we report a degradable poly(carboxybetaine) (pCB) hydrogel, produced via a thiol–disulfide exchange reaction for cell encapsulation. A pCB dithiol was synthesized as a cross-linker and reacted with a pyridyl dithiol-containing CB copolymer to form a hydrogel. We evaluated the biocompatibility of the pCB-based hydrogel via encapsulation of three cell types, including NIH3T3 fibroblasts, MG63 osteoblast-like cells, and HepG2 hepatocarcinoma cells. Up to 90% of cells retained their viability in the pCB hydrogel even at low cell-seeding densities under serum-free conditions after a 9-day culture. Results are compared with a degradable poly(ethylene glycol) methacrylate (PEGMA) hydrogel, which showed very low cell viability under serum-free condition after a 3-day culture. We incorporated an RGD peptide into the CB hydrogel using a cysteine-terminated cross-linker, which was shown to promote cell proliferation." @default.
• W2318041046 created "2016-06-24" @default.
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• W2318041046 date "2012-12-11" @default.
• W2318041046 modified "2023-10-18" @default.
• W2318041046 title "High Viability of Cells Encapsulated in Degradable Poly(carboxybetaine) Hydrogels" @default.
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• W2318041046 doi "https://doi.org/10.1021/la303390j" @default.
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