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- W2318049778 abstract "Introduction The clinical investigation project TOMMY suggests an alternative study to Total Body Irradiation (TBI): Total Marrow Irradiation (TMI) which reduces radiation doses to healthy tissues and allows dose escalation. We decided to study the feasibility of TMI using helical tomotherapy. Material and methods The output drift over 40 min was evaluated. The treatment planning was performed on a patient's CT with the following objective and constraints: D85 PTV = prescribed dose (12 Gy) and D50 OAR Results The estimated output drift is 1.7%. Treatment planning parameters were determined to have the optimum balance between PTV coverage and treatment time. The Results of treatment planning are consistent with values found in literature. Measured and calculated doses are in good agreement in an inhomogeneous and in a homogenous media. Nevertheless we notice that the dose measured with film is about 3% higher in the bone. In the junction region, inhomogeneity is less than ±2.5% for the ‘‘Full Tomo” method and inferior to ±3.5% for the ‘‘Linac-Tomo” method. Difference between in vivo measurements and calculated dose is inferior to 5%. Conclusion The feasibility study is conclusive, treatment planning objectives are achievable, presence of heterogeneities are well taken into account, in vivo and junction methods are validated." @default.
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- W2318049778 date "2013-06-01" @default.
- W2318049778 modified "2023-09-28" @default.
- W2318049778 title "Feasibility study of total marrow irradiation using helical tomotherapy" @default.
- W2318049778 doi "https://doi.org/10.1016/j.ejmp.2013.08.120" @default.
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