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- W2318062271 startingPage "430" @default.
- W2318062271 abstract "Cultured epidermal cells of explants from decubitus ulcer edges showed significant (P < 0.05) decreased maximal growth rate (range, 1.3–15.6%) and decreased area of outgrowth per explant (mean and SD, 1.6 ± 1.7 mm2) when compared with explants obtained 4–5 cm distant from the ulcer edge (range, 46.7–68.8% and 4.6 ± 2.7 mm2, respectively) and from healthy skin (range, 78.8–93.3% and 6.6 ± 1.2 mm2, respectively). In contrast, epidermal cells in biopsies from the ulcer edge were significantly (P < 0.05) more prevalent (range, 1.9–48.2%) as compared with biopsies of healthy skin (range, 3.1–5.1%). Therefore, the de-creased growth rate and decreased area of outgrowth may be caused by a defective migration potential rather than an impaired mitotic activity. The latter seems to be normal, as demonstrated by the histomorphometry, which indicates the in vivo situation. Decreased migration potential of epidermal cells could explain the clinically observed protracted epithelialization of decubitus ulcers." @default.
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- W2318062271 date "1989-10-01" @default.
- W2318062271 modified "2023-09-27" @default.
- W2318062271 title "Impaired Migration of Epidermal Cells from Decubitus Ulcers in Cell Cultures: A Cause of Protracted Wound Healing?" @default.
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- W2318062271 doi "https://doi.org/10.1093/ajcp/92.4.430" @default.
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