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• W2318091485 abstract "Systems analysis of chromatin has been constrained by complex patterns and dynamics of histone post-translational modifications (PTMs), which represent major challenges for both mass spectrometry (MS) and immuno-based approaches (e.g., chromatin immuno-precipitation, ChIP). Here we present a proof-of-concept study demonstrating that crosstalk among PTMs and their functional significance can be revealed via systematic bioinformatic and proteomic analysis of steady-state histone PTM levels from cells under various perturbations. Using high resolution tandem MS, we quantified 53 modification states from all core histones and their conserved variants in the unicellular eukaryotic model organism Tetrahymena. By correlating histone PTM patterns across 15 different conditions, including various physiological states and mutations of key histone modifying enzymes, we identified 5 specific chromatin states with characteristic covarying histone PTMs and associated them with distinctive functions in replication, transcription, and DNA repair. In addition to providing a detailed picture on histone PTM crosstalk at global levels, this work has established a novel bioinformatic and proteomic approach, which can be adapted to other organisms and readily scaled up to allow increased resolution of chromatin states." @default.
• W2318091485 created "2016-06-24" @default.
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• W2318091485 date "2014-06-13" @default.
• W2318091485 modified "2023-09-26" @default.
• W2318091485 title "Bioinformatic and Proteomic Analysis of Bulk Histones Reveals PTM Crosstalk and Chromatin Features" @default.
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• W2318091485 doi "https://doi.org/10.1021/pr5001829" @default.
• W2318091485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4096215" @default.
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