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- W2318154175 abstract "The vasodilatory effect of Globularia alypum L. (GA) extract was evaluated in rat mesenteric arterial bed pre-contracted by continuous infusion of phenylephrine (2–4 ng/mL). Bolus injections of GA elicited dose–response vasodilation, which was abolished after endothelium removal. Addition of a nitric oxide synthase inhibitor, N G -nitro-l-arginine methyl ester (100 µmol/L), alone or in the presence of a cyclooxygenase inhibitor, indomethacin (10 µmol/L), did not significantly affect the vasodilation of the mesenteric arterial bed in response to GA extract. These results suggest that GA-induced vasodilation is endothelium dependent but nitric oxide and prostacyclin independent. In the presence of high K + (60 mmol/L), the GA vasodilatory effect was completely abolished, suggesting that the vasodilation effect is mediated by hyperpolarization of the vascular cells. Also, pre-treatment with atropine (a muscarinic receptors antagonist) antagonized the GA-induced vasodilation, suggesting that the vasodilatory effect is mainly mediated by the endothelium-derived hyperpolarizing factor through activation of endothelial muscarinic receptors." @default.
- W2318154175 created "2016-06-24" @default.
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- W2318154175 date "2012-05-01" @default.
- W2318154175 modified "2023-09-27" @default.
- W2318154175 title "Endothelium-dependent vascular relaxation induced by <i>Globularia alypum</i> extract is mediated by EDHF in perfused rat mesenteric arterial bed" @default.
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- W2318154175 doi "https://doi.org/10.1139/y2012-035" @default.
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