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- W2318161504 abstract "Introduction: A perfusion system for human liver sections able to keep hepatic functionality for up to 30 hours was applied to study liver damage mediated by acetaminophen (APAP) in a human tissue based model. Methods: Perfusions were performed for 30 hours and hourly taken samples from the perfusate were analyzed for markers of general metabolism, hepatic synthesis capacity and liver cell damage. APAP was added after 8h with amounts relative to the liver weight (6.5 mg/g). N-Acetylcysteine was added after 20h to reduce liver damage in the course of perfusion. Liver function was determined by clearance of indocyanine green (ICG) after 4, 20 and 28h and normalized to the value at 4h. Results: ICG clearance in three liver sections perfused without APAP to obtain reference values was 98 ± 12% after 20h and 77 ± 18% after 28h. Liver function in two smaller liver sections (38 g) incubated with APAP was reduced to 41 and 71% after 20h and 22% after 28h, respectively. Liver function in two larger liver pieces (57 g) was dropped to 25 and 36% after 20h and to 18 and 10% after 28h, respectively, exhibiting nearly complete cell death at the end of experiment. Conclusion: The hepatotoxic sensitivity of the model with patient-relevant amounts of APAP was shown within the perfusion period. Further studies are required to investigate the optimal conditions to gain damaged, but not deceased tissue after 30h for subsequent analysis. Thus, this model is useful as human-based artificial liver system for the study of new drug candidates and pathologies of the liver." @default.
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- W2318161504 date "2015-01-16" @default.
- W2318161504 modified "2023-10-04" @default.
- W2318161504 title "Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections" @default.
- W2318161504 doi "https://doi.org/10.1055/s-0034-1397109" @default.
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