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- W2318173688 abstract "After spinal-cord injury, cells called astrocytes form a scar that is thought to block neuronal regeneration. The finding that the scar promotes regrowth of long nerve projections called axons challenges this long-held dogma. See Article p.195 It is widely believed that the astrocytic scars that develop following central nervous system (CNS) injury are a major obstacle to subsequent axonal regrowth. But here Michael Sofroniew and colleagues demonstrate that limiting the formation of the scar actually attenuates axon re-growth. Sustained delivery of axon-specific growth factors not typically present in spinal cord lesions allowed for robust re-growth, but only if the astrocytic scar was present. These results question the prevailing dogma and suggest that astrocyte scarring promotes — rather than prevents — CNS axon regeneration post-injury." @default.
- W2318173688 created "2016-06-24" @default.
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- W2318173688 date "2016-03-30" @default.
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- W2318173688 title "Not everything is scary about a glial scar" @default.
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- W2318173688 doi "https://doi.org/10.1038/nature17318" @default.
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