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• W2318199632 abstract "Oxidative damage to such biomolecules as DNA, lipids and proteins is involved in the process of aging and various diseases. In particular, DNA damage has strong influence on various cell functions, thereby being involved in aging and cancer. Oxidative DNA damage seems to be produced by oxidative stress in the body due to the increased production of oxygen radicals and decreased level of antioxidants. This paper reports the relationship between oxidative DNA damage and antioxidants in foods, and present information about the relationship, including analytical methods for assessing DNA damage and antioxidants in human samples. Among the antioxidants in foods, vitamin C, vitamin E, carotenoids, and flavonoids have received considerable attention in studies which evaluated their antioxidative effects in in vitro and in vivo. There have also been some clinical studies reporting the efficacy of these antioxidants against oxidative stress-induced DNA damage, although the results have been inconsistent, even in the case of vitamin C, a well-known antioxidant. The application of antioxidants to our practical eating habits for preventing oxidative DNA damage will therefore require further scientific findings on both their efficacy and safety." @default.
• W2318199632 created "2016-06-24" @default.
• W2318199632 creator A5032150734 @default.
• W2318199632 date "2004-01-01" @default.
• W2318199632 modified "2023-09-30" @default.
• W2318199632 title "Antioxidative Nutrients and Oxidative DNA Damage" @default.
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• W2318199632 doi "https://doi.org/10.5264/eiyogakuzashi.62.65" @default.
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