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- W2318219825 abstract "Background Recent models on metastatic invasion focus on the tumor-“host” interface, in particular the role of the stromal tissue. The stromal compartments are thought to play a major role in the process of wound healing, but there is also strong emphasis that CAF9s (cancer-associated fibroblasts) are important promotors for tumor growth and progression. Assuming these models are correct we hypothesized that changes in the proportion of stroma in the primary tumor could reflect progression. We therefore investigated if the amount of intra-tumor stroma could be used as a candidate marker to identify which patients should be selected for adjuvant therapy and furthermore if treatment with a COX-2 inhibitor might improve patient outcome in those patients with high percentage of stroma (with or without chemotherapy) Methods We have investigated the proportion of intra-tumor stroma on heamatoxylin-eosin (HE DFS p=0.0002, HZ 2.31). A high-risk group (n=14) was identified with stroma-high and SMAD4 loss (OS p=0.008, HZ 7.98, CI 4.12-15.44, DFS p=0.005, HZ 6.57, CI 3.43-12.56); 12 of 14 (85.7%) patients died within 3 years. In a logistic-regression analysis a high proportion of stroma and SMAD4 loss were strongly related (HZ 5.42, CI 2.13-13.82, p Results of the COX-2 inhibitor study are currently under evaluation but will be presented at the conference. Conclusions: Conventional haematoxylin-eosin stained tumor slides contain more prognostic information than previously fathomed. This can be utilized by assessing the tumor-stroma ratio. The combination of analyzing the tumor-stroma ratio and staining for SMAD4 results in an independent parameter for confident prediction of clinical outcome. The inclusion of this parameter into standard pathological reports should be considered, in addition to the TNM classification. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 811." @default.
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- W2318219825 date "2010-04-15" @default.
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- W2318219825 title "Abstract 811: Stroma production within the primary tumor correlates with poor survival for stage I-II colon cancer patients" @default.
- W2318219825 doi "https://doi.org/10.1158/1538-7445.am10-811" @default.
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