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- W2318278318 abstract "Aims: Dementia is common among the elderly but it can also affect the younger age group. Cholinesterase inhibitors (ChEI) in Alzheimer Dementia (AD) are extensively studied and widely used. This case report aims to illustrate the usefulness of ChEIs in other non–age related neurodegenerative dementias apart from AD. Presentation of Cases: Four cases in which ChEIs was found to be useful in improving the cognition following Traumatic Brain Injury, Nipah Encephalitis, Cerebral Malaria and Meningoencephalitis. All the four cases were prescribed ChEIs and were followed up in a Memory Clinic. All of them showed substantial and sustained cognitive improvement. Discussion: Traumatic brain injury causes axonal swelling with accumulation of beta-amyloid and alters progranulin metabolism. Nipah Virus infection of brain parenchyma causes vasculitis, endothelial damage and micro-infarction. While in cerebral malaria, infected and non-infected erythrocytes within the cerebral vessels reduces microvascular flow and initiates inflammatory cascade. Infective encephalitis causes neurotoxin production and inflammatory process. These pathological processes reduce cerebral neurotransmitters concentration including acetylcholine. Cholinesterase inhibitors enhance cognitive function by increasing the amount of acetylcholine at the neuronal synaptic cleft. This clinical significance may be extended to patients with cognitive impairments other than AD." @default.
- W2318278318 created "2016-06-24" @default.
- W2318278318 creator A5067666594 @default.
- W2318278318 date "2015-01-10" @default.
- W2318278318 modified "2023-09-27" @default.
- W2318278318 title "Cholinesterase Inhibitors in Non-age Related Neurodegenerative Dementias" @default.
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- W2318278318 doi "https://doi.org/10.9734/indj/2015/12752" @default.
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