Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318281771> ?p ?o ?g. }
- W2318281771 endingPage "1475" @default.
- W2318281771 startingPage "1469" @default.
- W2318281771 abstract "5-Azacytidine is a cytidine analogue that is capable of activating repressed genes in tissue-culture cells and has been shown to increase hemoglobin-F production in anemic baboons. This drug was administered to a patient with severe β-thalassemia in an attempt to stimulate hemoglobin-F production. After seven days of 5-azacytidine treatment, γ-globin synthesis increased approximately sevenfold, temporarily normalizing the patient's unbalanced globin synthesis. Erythropoiesis became more effective, leading to a temporary increase in the absolute reticulocyte count (from 5000 to 22,000 per cubic millimeter) and in hemoglobin concentration (from 8.0 to 10.8 g per deciliter). Hypomethylation of bone-marrow DNA near both the γ-globin and ε-globin genes was directly demonstrated. At the time of peak drug effect, about 7000 γ-globin messenger RNA molecules were present per erythroid bone-marrow cell, in contrast to 10 to 15 ε-globin messenger RNA molecules per cell. 5-Azacytidine selectively increases γ-globin synthesis and therefore provides a new approach to the treatment of severe β-thalassemia. Further studies will be required to evaluate the efficacy, risks, and long-term toxicity of 5-azacytidine (or related compounds) before this approach can be used as a therapy for patients with disorders of hemoglobin synthesis. (N Engl J Med. 1982; 307:1469–75.)" @default.
- W2318281771 created "2016-06-24" @default.
- W2318281771 creator A5022822892 @default.
- W2318281771 creator A5023605713 @default.
- W2318281771 creator A5024703985 @default.
- W2318281771 creator A5035712259 @default.
- W2318281771 creator A5040276909 @default.
- W2318281771 creator A5057387604 @default.
- W2318281771 creator A5062432406 @default.
- W2318281771 creator A5072572335 @default.
- W2318281771 creator A5076646829 @default.
- W2318281771 date "1982-12-09" @default.
- W2318281771 modified "2023-10-10" @default.
- W2318281771 title "5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β<sup>+</sup>Thalassemia" @default.
- W2318281771 cites W1484043176 @default.
- W2318281771 cites W1489701268 @default.
- W2318281771 cites W1528346173 @default.
- W2318281771 cites W1969774671 @default.
- W2318281771 cites W1970078675 @default.
- W2318281771 cites W1981475367 @default.
- W2318281771 cites W1984924023 @default.
- W2318281771 cites W1987155442 @default.
- W2318281771 cites W1994268106 @default.
- W2318281771 cites W1996043889 @default.
- W2318281771 cites W1997827286 @default.
- W2318281771 cites W2007230848 @default.
- W2318281771 cites W2016197401 @default.
- W2318281771 cites W2018319796 @default.
- W2318281771 cites W2022963870 @default.
- W2318281771 cites W2023374624 @default.
- W2318281771 cites W2026969402 @default.
- W2318281771 cites W2027782583 @default.
- W2318281771 cites W2048404769 @default.
- W2318281771 cites W2049894794 @default.
- W2318281771 cites W2053137955 @default.
- W2318281771 cites W2063450941 @default.
- W2318281771 cites W2066960428 @default.
- W2318281771 cites W2073246218 @default.
- W2318281771 cites W2074534353 @default.
- W2318281771 cites W2077077811 @default.
- W2318281771 cites W2087909223 @default.
- W2318281771 cites W2145750252 @default.
- W2318281771 cites W2271710655 @default.
- W2318281771 cites W2409557754 @default.
- W2318281771 cites W253845798 @default.
- W2318281771 cites W4243787970 @default.
- W2318281771 doi "https://doi.org/10.1056/nejm198212093072401" @default.
- W2318281771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6183586" @default.
- W2318281771 hasPublicationYear "1982" @default.
- W2318281771 type Work @default.
- W2318281771 sameAs 2318281771 @default.
- W2318281771 citedByCount "479" @default.
- W2318281771 countsByYear W23182817712012 @default.
- W2318281771 countsByYear W23182817712013 @default.
- W2318281771 countsByYear W23182817712014 @default.
- W2318281771 countsByYear W23182817712015 @default.
- W2318281771 countsByYear W23182817712016 @default.
- W2318281771 countsByYear W23182817712017 @default.
- W2318281771 countsByYear W23182817712018 @default.
- W2318281771 countsByYear W23182817712019 @default.
- W2318281771 countsByYear W23182817712020 @default.
- W2318281771 countsByYear W23182817712021 @default.
- W2318281771 countsByYear W23182817712022 @default.
- W2318281771 countsByYear W23182817712023 @default.
- W2318281771 crossrefType "journal-article" @default.
- W2318281771 hasAuthorship W2318281771A5022822892 @default.
- W2318281771 hasAuthorship W2318281771A5023605713 @default.
- W2318281771 hasAuthorship W2318281771A5024703985 @default.
- W2318281771 hasAuthorship W2318281771A5035712259 @default.
- W2318281771 hasAuthorship W2318281771A5040276909 @default.
- W2318281771 hasAuthorship W2318281771A5057387604 @default.
- W2318281771 hasAuthorship W2318281771A5062432406 @default.
- W2318281771 hasAuthorship W2318281771A5072572335 @default.
- W2318281771 hasAuthorship W2318281771A5076646829 @default.
- W2318281771 hasConcept C104317684 @default.
- W2318281771 hasConcept C105580179 @default.
- W2318281771 hasConcept C125996951 @default.
- W2318281771 hasConcept C126322002 @default.
- W2318281771 hasConcept C150194340 @default.
- W2318281771 hasConcept C153911025 @default.
- W2318281771 hasConcept C172680121 @default.
- W2318281771 hasConcept C181199279 @default.
- W2318281771 hasConcept C190727270 @default.
- W2318281771 hasConcept C2776239401 @default.
- W2318281771 hasConcept C2776317666 @default.
- W2318281771 hasConcept C2777799968 @default.
- W2318281771 hasConcept C2778248108 @default.
- W2318281771 hasConcept C2778403015 @default.
- W2318281771 hasConcept C2778917026 @default.
- W2318281771 hasConcept C2779234561 @default.
- W2318281771 hasConcept C2779703530 @default.
- W2318281771 hasConcept C2780007613 @default.
- W2318281771 hasConcept C2780844101 @default.
- W2318281771 hasConcept C2781184954 @default.
- W2318281771 hasConcept C54355233 @default.
- W2318281771 hasConcept C55493867 @default.
- W2318281771 hasConcept C71924100 @default.
- W2318281771 hasConcept C86803240 @default.