FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318293625> ?p ?o ?g. }

• W2318293625 abstract "The countries of Central and Eastern Europe have among the highest worldwide rates of renal cell cancer. Few studies have examined whether genetic variation in xenobiotic metabolic pathway genes may modify risk for this cancer. The Central and Eastern Europe Renal Cell Cancer study was a hospital-based case-control study conducted between 1998 and 2003 across seven centers in central and eastern Europe. The study centers were in the Czech Republic (Ceske, Prague, Olomouc, Brno), Poland (Lodz), Romania (Bucharest), and Russia (Moscow). Incident cases of primary kidney cancer were recruited and underwent an in-person interview in which detailed data were collected on demographics as well as work history and occupational exposure to chemical agents. Genes (cytochrome P-450 family, N-acetyltransferases, NAD(P)H:quinone oxidoreductase I (NQO1), microsomal epoxide hydrolase (mEH), catechol-O-methyltransferase (COMT)) were selected for the present analysis based on their putative role in xenobiotic metabolism. Genotyping (874 cases and 2396 controls) was conducted with a GoldenGate® Oligo Pool All (OPA) assay by Illumina® and the 5’ nuclease assay (Taqman, Applied Biosystems). Haplotypes were calculated using fastPhase. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression adjusted for country of residence, age, and sex. We observed an increased risk of renal cell cancer (RCC) with two NAT1 SNPs (NAT1A40T, OR=1.36, CI 1.00, 1.86; NAT1R187Q, OR=1.65, CI 1.01, 2.71) and with CYP1B1V432L (OR=1.14, CI 1.01, 1.28). The slow (NAT1*14) phenotype was associated with increased risk of RCC (OR=1.69, CI 1.00-2.86) in comparison to normal phenotype (NAT1*4, *3, *11). Among persons with NAT1*14 phenotype, occupational exposure to trichloroethylene (OR=9.94, CI 1.15, 86.1) and chlorinated solvents (OR=9.79, CI 1.13, 84.8) conferred an increased risk of RCC. Among those with the CYP1B1V432L variant, occupational exposure to trichloroethylene (OR=1.68, CI 1.21, 2.34) and chlorinated solvents (OR=1.58, CI 1.14, 2.19) also had increased risk of RCC. These results require replication, but provide evidence that the relationship between certain agents and RCC may be modified by particular variants in xenobiotic metabolism genes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 915." @default.
• W2318293625 created "2016-06-24" @default.
• W2318293625 creator A5000877350 @default.
• W2318293625 creator A5001857260 @default.
• W2318293625 creator A5002554548 @default.
• W2318293625 creator A5011467039 @default.
• W2318293625 creator A5014404772 @default.
• W2318293625 creator A5017309816 @default.
• W2318293625 creator A5020712297 @default.
• W2318293625 creator A5021007602 @default.
• W2318293625 creator A5023267437 @default.
• W2318293625 creator A5043315482 @default.
• W2318293625 creator A5055527284 @default.
• W2318293625 creator A5055784647 @default.
• W2318293625 creator A5057649971 @default.
• W2318293625 creator A5072121317 @default.
• W2318293625 creator A5073984505 @default.
• W2318293625 creator A5077540587 @default.
• W2318293625 creator A5079944764 @default.
• W2318293625 creator A5089473534 @default.
• W2318293625 creator A5091859226 @default.
• W2318293625 date "2010-04-15" @default.
• W2318293625 modified "2023-10-18" @default.
• W2318293625 title "Abstract 915: Xenobiotic metabolizing gene variants, occupational chemical exposures, and renal cell cancer" @default.
• W2318293625 doi "https://doi.org/10.1158/1538-7445.am10-915" @default.
• W2318293625 hasPublicationYear "2010" @default.
• W2318293625 type Work @default.
• W2318293625 sameAs 2318293625 @default.
• W2318293625 citedByCount "0" @default.
• W2318293625 crossrefType "proceedings-article" @default.
• W2318293625 hasAuthorship W2318293625A5000877350 @default.
• W2318293625 hasAuthorship W2318293625A5001857260 @default.
• W2318293625 hasAuthorship W2318293625A5002554548 @default.
• W2318293625 hasAuthorship W2318293625A5011467039 @default.
• W2318293625 hasAuthorship W2318293625A5014404772 @default.
• W2318293625 hasAuthorship W2318293625A5017309816 @default.
• W2318293625 hasAuthorship W2318293625A5020712297 @default.
• W2318293625 hasAuthorship W2318293625A5021007602 @default.
• W2318293625 hasAuthorship W2318293625A5023267437 @default.
• W2318293625 hasAuthorship W2318293625A5043315482 @default.
• W2318293625 hasAuthorship W2318293625A5055527284 @default.
• W2318293625 hasAuthorship W2318293625A5055784647 @default.
• W2318293625 hasAuthorship W2318293625A5057649971 @default.
• W2318293625 hasAuthorship W2318293625A5072121317 @default.
• W2318293625 hasAuthorship W2318293625A5073984505 @default.
• W2318293625 hasAuthorship W2318293625A5077540587 @default.
• W2318293625 hasAuthorship W2318293625A5079944764 @default.
• W2318293625 hasAuthorship W2318293625A5089473534 @default.
• W2318293625 hasAuthorship W2318293625A5091859226 @default.
• W2318293625 hasConcept C101819947 @default.
• W2318293625 hasConcept C104317684 @default.
• W2318293625 hasConcept C121608353 @default.
• W2318293625 hasConcept C126322002 @default.
• W2318293625 hasConcept C135763542 @default.
• W2318293625 hasConcept C143998085 @default.
• W2318293625 hasConcept C156957248 @default.
• W2318293625 hasConcept C202751555 @default.
• W2318293625 hasConcept C2776671928 @default.
• W2318293625 hasConcept C2781068499 @default.
• W2318293625 hasConcept C31467283 @default.
• W2318293625 hasConcept C54355233 @default.
• W2318293625 hasConcept C71924100 @default.
• W2318293625 hasConcept C86803240 @default.
• W2318293625 hasConcept C87644729 @default.
• W2318293625 hasConceptScore W2318293625C101819947 @default.
• W2318293625 hasConceptScore W2318293625C104317684 @default.
• W2318293625 hasConceptScore W2318293625C121608353 @default.
• W2318293625 hasConceptScore W2318293625C126322002 @default.
• W2318293625 hasConceptScore W2318293625C135763542 @default.
• W2318293625 hasConceptScore W2318293625C143998085 @default.
• W2318293625 hasConceptScore W2318293625C156957248 @default.
• W2318293625 hasConceptScore W2318293625C202751555 @default.
• W2318293625 hasConceptScore W2318293625C2776671928 @default.
• W2318293625 hasConceptScore W2318293625C2781068499 @default.
• W2318293625 hasConceptScore W2318293625C31467283 @default.
• W2318293625 hasConceptScore W2318293625C54355233 @default.
• W2318293625 hasConceptScore W2318293625C71924100 @default.
• W2318293625 hasConceptScore W2318293625C86803240 @default.
• W2318293625 hasConceptScore W2318293625C87644729 @default.
• W2318293625 hasLocation W23182936251 @default.
• W2318293625 hasOpenAccess W2318293625 @default.
• W2318293625 hasPrimaryLocation W23182936251 @default.
• W2318293625 hasRelatedWork W1977824400 @default.
• W2318293625 hasRelatedWork W2029798531 @default.
• W2318293625 hasRelatedWork W2063841367 @default.
• W2318293625 hasRelatedWork W2064902919 @default.
• W2318293625 hasRelatedWork W2075959498 @default.
• W2318293625 hasRelatedWork W2087723915 @default.
• W2318293625 hasRelatedWork W2129240520 @default.
• W2318293625 hasRelatedWork W2134628271 @default.
• W2318293625 hasRelatedWork W2161150047 @default.
• W2318293625 hasRelatedWork W2187813511 @default.
• W2318293625 hasRelatedWork W2274968383 @default.
• W2318293625 hasRelatedWork W2384585895 @default.
• W2318293625 hasRelatedWork W2404617168 @default.
• W2318293625 hasRelatedWork W2734594307 @default.
• W2318293625 hasRelatedWork W2734986458 @default.
• W2318293625 hasRelatedWork W2765135904 @default.
• W2318293625 hasRelatedWork W3126760223 @default.
• W2318293625 hasRelatedWork W3991422 @default.

• next