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- W2318302040 abstract "Using buformin hydrochloride, a highly water-soluble drug, as a model drug, a sustainedrelease dosage form was developed. Six granule formulations were prepared from corn starchlactose, synthetic aluminum silicate, ethyl cellulose, and polymethylmethacrylate, and five tablet formulations were prepared from corn starch-lactose, calcium hydrogen phosphate, crystalline cellulose, ethyl cellulose, and sodium polyacrylate. These formulations were subjected to dissolution tests for in vitro screening of potential retard forms. It was found that incorporation of sodium polyacrylate was very effective in reducing the release rate. Two formulations incorporating sodium polyacrylate were selected as the most successful retard forms in an in vitro study. They were orally administered to beagle dogs for in vivo evaluation. It was concluded that this material is one of the most promising excipients for a sustained-release dosage form which contains an extremely water-soluble drug." @default.
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- W2318302040 date "1984-01-01" @default.
- W2318302040 modified "2023-09-25" @default.
- W2318302040 title "Sustained-release formulation of buformin hydrochloride." @default.
- W2318302040 cites W289778840 @default.
- W2318302040 doi "https://doi.org/10.1248/cpb.32.1049" @default.
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