FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318366935> ?p ?o ?g. }

• W2318366935 endingPage "755" @default.
• W2318366935 startingPage "743" @default.
• W2318366935 abstract "We hypothesized that DNA methylation patterns may contribute to disease severity or the development of hypertension and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA). Illumina's (San Diego, CA, USA) DNA methylation 27-K assay was used to identify differentially methylated loci (DML). DNA methylation levels were validated by pyrosequencing. A discovery cohort of 15 patients with OSA and 6 healthy subjects, and a validation cohort of 72 patients with sleep disordered breathing (SDB). Microarray analysis identified 636 DMLs in patients with OSA versus healthy subjects, and 327 DMLs in patients with OSA and hypertension versus those without hypertension. In the validation cohort, no significant difference in DNA methylation levels of six selected genes was found between the primary snoring subjects and OSA patients (primary outcome). However, a secondary outcome analysis showed that interleukin-1 receptor 2 (IL1R2) promoter methylation (−114 cytosine followed by guanine dinucleotide sequence [CpG] site) was decreased and IL1R2 protein levels were increased in the patients with SDB with an oxygen desaturation index > 30. Androgen receptor (AR) promoter methylation (−531 CpG site) and AR protein levels were both increased in the patients with SDB with an oxygen desaturation index > 30. Natriuretic peptide receptor 2 (NPR2) promoter methylation (−608/−618 CpG sites) were decreased, whereas levels of both NPR2 and serum C type natriuretic peptide protein were increased in the SDB patients with EDS. Speckled protein 140 (SP140) promoter methylation (−194 CpG site) was increased, and SP140 protein levels were decreased in the patients with SDB and EDS. IL1R2 hypomethylation and AR hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to EDS in OSA. A commentary on this article appears in this issue on page 723. This is the first study to perform a large-scale DNA methylation analysis with replication of the principal finding in OSA patients. The identification of the abnormal DNA methylation marks in OSA provides novel biomarkers for prediction and diagnosis, and affords novel therapeutic targets for the prevention of adverse consequences of OSA. Further investigation is required to clarify whether these changes in peripheral blood mononuclear cells can be translated to neurons, endothelium, or other end-organ tissues, and to clarify the cause-and-effect relationship between the DNA methylation changes and the development of clinical phenotypes of OSA syndrome." @default.
• W2318366935 created "2016-06-24" @default.
• W2318366935 creator A5000251879 @default.
• W2318366935 creator A5010766278 @default.
• W2318366935 creator A5014564819 @default.
• W2318366935 creator A5016280117 @default.
• W2318366935 creator A5017116368 @default.
• W2318366935 creator A5018591572 @default.
• W2318366935 creator A5019137138 @default.
• W2318366935 creator A5035279380 @default.
• W2318366935 creator A5040425523 @default.
• W2318366935 creator A5055605789 @default.
• W2318366935 creator A5057835793 @default.
• W2318366935 creator A5065376505 @default.
• W2318366935 creator A5070320351 @default.
• W2318366935 creator A5077098079 @default.
• W2318366935 creator A5082776397 @default.
• W2318366935 date "2016-04-01" @default.
• W2318366935 modified "2023-10-18" @default.
• W2318366935 title "Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea:<i>IL1R2,</i><i>NPR2</i>,<i>AR</i>,<i>SP140</i>Methylation and Clinical Phenotype" @default.
• W2318366935 cites W100020802 @default.
• W2318366935 cites W1491734076 @default.
• W2318366935 cites W1572338224 @default.
• W2318366935 cites W1968218641 @default.
• W2318366935 cites W1969518444 @default.
• W2318366935 cites W1970950058 @default.
• W2318366935 cites W1972169553 @default.
• W2318366935 cites W1977968916 @default.
• W2318366935 cites W1979924825 @default.
• W2318366935 cites W1985221989 @default.
• W2318366935 cites W1985837958 @default.
• W2318366935 cites W1988142188 @default.
• W2318366935 cites W1991376073 @default.
• W2318366935 cites W1994082232 @default.
• W2318366935 cites W2000648487 @default.
• W2318366935 cites W2004333683 @default.
• W2318366935 cites W2004635300 @default.
• W2318366935 cites W2012385104 @default.
• W2318366935 cites W2012430427 @default.
• W2318366935 cites W2013521626 @default.
• W2318366935 cites W2018493244 @default.
• W2318366935 cites W2025674081 @default.
• W2318366935 cites W2027592271 @default.
• W2318366935 cites W2029751590 @default.
• W2318366935 cites W2034095910 @default.
• W2318366935 cites W2035271053 @default.
• W2318366935 cites W2037793634 @default.
• W2318366935 cites W2040813956 @default.
• W2318366935 cites W2041911587 @default.
• W2318366935 cites W2041980787 @default.
• W2318366935 cites W2046291064 @default.
• W2318366935 cites W2056040742 @default.
• W2318366935 cites W2058640777 @default.
• W2318366935 cites W2067400934 @default.
• W2318366935 cites W2086155425 @default.
• W2318366935 cites W2087352272 @default.
• W2318366935 cites W2109674742 @default.
• W2318366935 cites W2120572713 @default.
• W2318366935 cites W2120693890 @default.
• W2318366935 cites W2134575578 @default.
• W2318366935 cites W2142125312 @default.
• W2318366935 cites W2150687550 @default.
• W2318366935 cites W2156389796 @default.
• W2318366935 cites W2157275351 @default.
• W2318366935 cites W2160358826 @default.
• W2318366935 cites W2163125553 @default.
• W2318366935 cites W2330132183 @default.
• W2318366935 cites W26912437 @default.
• W2318366935 doi "https://doi.org/10.5665/sleep.5620" @default.
• W2318366935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4791608" @default.
• W2318366935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26888452" @default.
• W2318366935 hasPublicationYear "2016" @default.
• W2318366935 type Work @default.
• W2318366935 sameAs 2318366935 @default.
• W2318366935 citedByCount "39" @default.
• W2318366935 countsByYear W23183669352016 @default.
• W2318366935 countsByYear W23183669352017 @default.
• W2318366935 countsByYear W23183669352018 @default.
• W2318366935 countsByYear W23183669352019 @default.
• W2318366935 countsByYear W23183669352020 @default.
• W2318366935 countsByYear W23183669352021 @default.
• W2318366935 countsByYear W23183669352022 @default.
• W2318366935 countsByYear W23183669352023 @default.
• W2318366935 crossrefType "journal-article" @default.
• W2318366935 hasAuthorship W2318366935A5000251879 @default.
• W2318366935 hasAuthorship W2318366935A5010766278 @default.
• W2318366935 hasAuthorship W2318366935A5014564819 @default.
• W2318366935 hasAuthorship W2318366935A5016280117 @default.
• W2318366935 hasAuthorship W2318366935A5017116368 @default.
• W2318366935 hasAuthorship W2318366935A5018591572 @default.
• W2318366935 hasAuthorship W2318366935A5019137138 @default.
• W2318366935 hasAuthorship W2318366935A5035279380 @default.
• W2318366935 hasAuthorship W2318366935A5040425523 @default.
• W2318366935 hasAuthorship W2318366935A5055605789 @default.
• W2318366935 hasAuthorship W2318366935A5057835793 @default.
• W2318366935 hasAuthorship W2318366935A5065376505 @default.
• W2318366935 hasAuthorship W2318366935A5070320351 @default.
• W2318366935 hasAuthorship W2318366935A5077098079 @default.

• next