Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318372282> ?p ?o ?g. }
- W2318372282 endingPage "976" @default.
- W2318372282 startingPage "968" @default.
- W2318372282 abstract "SelW, a protein containing a selenocysteine (Sec) in a conserved Cys-X-X-Sec motif, has been suggested to have an antioxidant role in cell metabolism. SelW is known to specifically interact with different isoforms of 14-3-3 proteins. The latter are involved in several cellular processes such as regulation of the cell cycle, metabolism control, apoptosis, protein trafficking, and gene transcription. 14-3-3 proteins feature a conserved solvent-exposed cysteine residue, in a surface environment prone to induce chemical modifications of the thiol functionality following oxidative stress. The structures of 12 homologous complexes between SelW and 14-3-3 were calculated using sequential alignments, molecular modeling, and docking algorithms guided by known experimental NMR data. These structures reveal the viability of a protein complex in which the conserved Sec residue on SelW approaches the conserved exposed Cys on 14-3-3, making a plausible Sec-Se-S-Cys bond. On the basis of the structural information derived from these calculations, we propose a working hypothesis that entails a role for SelW as a physiological partner of 14-3-3 proteins, able to facilitate a redox-based regulation mechanism." @default.
- W2318372282 created "2016-06-24" @default.
- W2318372282 creator A5028291613 @default.
- W2318372282 creator A5052677921 @default.
- W2318372282 creator A5084209406 @default.
- W2318372282 date "2011-02-07" @default.
- W2318372282 modified "2023-10-18" @default.
- W2318372282 title "Interaction of Selenoprotein W with 14-3-3 Proteins: A Computational Approach" @default.
- W2318372282 cites W141477066 @default.
- W2318372282 cites W1965483278 @default.
- W2318372282 cites W1966441851 @default.
- W2318372282 cites W1967525983 @default.
- W2318372282 cites W1969007008 @default.
- W2318372282 cites W1969234662 @default.
- W2318372282 cites W1985448020 @default.
- W2318372282 cites W1986191025 @default.
- W2318372282 cites W1996662763 @default.
- W2318372282 cites W2009179936 @default.
- W2318372282 cites W2011845231 @default.
- W2318372282 cites W2013452582 @default.
- W2318372282 cites W2014433643 @default.
- W2318372282 cites W2016269899 @default.
- W2318372282 cites W2020285880 @default.
- W2318372282 cites W2021534482 @default.
- W2318372282 cites W2027572818 @default.
- W2318372282 cites W2034359860 @default.
- W2318372282 cites W2038496059 @default.
- W2318372282 cites W2044694582 @default.
- W2318372282 cites W2050938499 @default.
- W2318372282 cites W2058017150 @default.
- W2318372282 cites W2061834818 @default.
- W2318372282 cites W2065283382 @default.
- W2318372282 cites W2065773243 @default.
- W2318372282 cites W2066244933 @default.
- W2318372282 cites W2075369230 @default.
- W2318372282 cites W2076367848 @default.
- W2318372282 cites W2083240338 @default.
- W2318372282 cites W2089600895 @default.
- W2318372282 cites W2094305716 @default.
- W2318372282 cites W2106882534 @default.
- W2318372282 cites W2107919301 @default.
- W2318372282 cites W2111387452 @default.
- W2318372282 cites W2112743424 @default.
- W2318372282 cites W2113617470 @default.
- W2318372282 cites W2117436673 @default.
- W2318372282 cites W2122219583 @default.
- W2318372282 cites W2125935300 @default.
- W2318372282 cites W2132629607 @default.
- W2318372282 cites W2134059200 @default.
- W2318372282 cites W2134731229 @default.
- W2318372282 cites W2135815512 @default.
- W2318372282 cites W2147158306 @default.
- W2318372282 cites W2156876367 @default.
- W2318372282 cites W2158714788 @default.
- W2318372282 cites W2166317516 @default.
- W2318372282 cites W2167837750 @default.
- W2318372282 cites W2168433858 @default.
- W2318372282 cites W4245543343 @default.
- W2318372282 cites W4248959081 @default.
- W2318372282 doi "https://doi.org/10.1021/pr101178k" @default.
- W2318372282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21182337" @default.
- W2318372282 hasPublicationYear "2011" @default.
- W2318372282 type Work @default.
- W2318372282 sameAs 2318372282 @default.
- W2318372282 citedByCount "28" @default.
- W2318372282 countsByYear W23183722822012 @default.
- W2318372282 countsByYear W23183722822013 @default.
- W2318372282 countsByYear W23183722822014 @default.
- W2318372282 countsByYear W23183722822015 @default.
- W2318372282 countsByYear W23183722822016 @default.
- W2318372282 countsByYear W23183722822017 @default.
- W2318372282 countsByYear W23183722822018 @default.
- W2318372282 countsByYear W23183722822019 @default.
- W2318372282 countsByYear W23183722822020 @default.
- W2318372282 countsByYear W23183722822021 @default.
- W2318372282 countsByYear W23183722822022 @default.
- W2318372282 countsByYear W23183722822023 @default.
- W2318372282 crossrefType "journal-article" @default.
- W2318372282 hasAuthorship W2318372282A5028291613 @default.
- W2318372282 hasAuthorship W2318372282A5052677921 @default.
- W2318372282 hasAuthorship W2318372282A5084209406 @default.
- W2318372282 hasConcept C104317684 @default.
- W2318372282 hasConcept C11804247 @default.
- W2318372282 hasConcept C159110408 @default.
- W2318372282 hasConcept C167625842 @default.
- W2318372282 hasConcept C181199279 @default.
- W2318372282 hasConcept C185592680 @default.
- W2318372282 hasConcept C199216141 @default.
- W2318372282 hasConcept C2776087148 @default.
- W2318372282 hasConcept C2779201268 @default.
- W2318372282 hasConcept C41685203 @default.
- W2318372282 hasConcept C55493867 @default.
- W2318372282 hasConcept C70721500 @default.
- W2318372282 hasConcept C71924100 @default.
- W2318372282 hasConcept C86803240 @default.
- W2318372282 hasConceptScore W2318372282C104317684 @default.
- W2318372282 hasConceptScore W2318372282C11804247 @default.
- W2318372282 hasConceptScore W2318372282C159110408 @default.