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- W2318373073 abstract "Abstract Background Diabetes has a deleterious effect on clinical status in children with Cystic Fibrosis (CF). We hypothesized that children with CF Related Diabetes (CFRD) or Impaired Glucose Tolerance (IGT) would have more rapidly progressive lung disease based on chest computed tomography (CT) than those with normal glucose tolerance (NGT). Methods In a retrospective study we compared lung structure changes over time, as assessed by CT, in 34 CF children with CFRD, IGT or NGT. We then compared CT findings with changes in lung function. Results Percentage forced expiratory volume in 1s (%FEV 1 ) remained stable over time with a mean (±SD) yearly change of −0.5% (±3.9), −0.4% (±2.3) and −0.85% (±2.8) (p=0.92) for the CFRD, IGT and NGT groups respectively. However, there was a mean (95%CI) increase in % CT score of 3.86%/year (1.77–5.95%), 1.59%/year (0.6–2.58%) and 1.09%/year (0.07–2.11%) (p=0.023). Conclusion In patients with CFRD, there was a more rapid progression of structural lung disease, compared to those who had NGT that was not reflected by change in lung function." @default.
- W2318373073 created "2016-06-24" @default.
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- W2318373073 date "2010-05-01" @default.
- W2318373073 modified "2023-09-25" @default.
- W2318373073 title "Progression Of Structural Lung Disease On CT Scans In Children With Cystic Fibrosis Related Diabetes" @default.
- W2318373073 doi "https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1834" @default.
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