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• W2318374523 abstract "On the pathogenesis of myocardial infarction, there have been many works particularly with reference to coronary sclerosis, blood coagulation and stress. In recent years patients with myocardial infarction have been treated with anticoagulant. The subject of this treatment is to prevent the attacks of myocardial infarction by reducing blood coagulability with anticoagulant. However, the therapeutic and preventive effect of this treatment is not yet exactly established. In this paper it will be presented the results of experimental studies performed with reference to the role of blood coagulation and the effect of anticoagulant therapy in the prevention of infarction. Methods and Materials. In the experiments, rabbits were used, coronary sclerosis and myocardial infarction were produced by the injection of allylamine and homologous rabbit serum. Twenty female rabbits, weighed 2 to 3 kg., were divided into 4 groups A, B, C and D. Group A was given intravenously 15 mg/kg of allylamine 20 times and then 30 mg/kg 10 times every other day. Group B was given 2 ml of rabbit serum intravenously every other day after the treatment of allylamine as group A. Group C was given Warfarin orally after the treatment as group A and then injected rabbit serum as group B. During these procedure prothrombin was maintained as to keep the level of 10 to 25 per cent of normal. Group D was injected rabbit serum only. In each group, blood clotting factors were estimated and they were examined occasionally by electrocardiography. All servived rabbits were killed on about 100 days from the first injection of rabbit serum and investigated histologically. Prothrombin was estimated by Quick's one stage method. Factor V was determined by Wolf's method modified by MATSUOKA. Factor VII was estimated by Koller's method. Thromboplastin generation test was performed as described by BIGGS and DOUGLAS. Fibrinogen was estimated by tyrosine method. Whole blood clotting time was estimated by the method of LEE-WHITE." @default.
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• W2318374523 date "1965-01-01" @default.
• W2318374523 modified "2023-09-26" @default.
• W2318374523 title "Studies on the Pathogenesis of Myocardial Infarction and Its Prevention Especially with Anticoagulant" @default.
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• W2318374523 doi "https://doi.org/10.1253/jcj.29.393" @default.
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