Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318384586> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2318384586 endingPage "P67" @default.
- W2318384586 startingPage "P67" @default.
- W2318384586 abstract "BACKGROUND The increasing interest in applying therapeutic drug monitoring (TDM) to antiretroviral therapy is related to the inter-individual variation in antiretroviral pharmacokinetics. This variation may be due to certain genetic variations such as the efflux pump P-glycoprotein MDR1 polymorphisms G2677T and C3435T. METHOD To facilitate the application of TDM, a real-time PCR based genotyping method for the detection of MDR1 polymorphisms was developed in 62 HIV-positive patients. This method was used to determine the MDR1 genotypes in both substance abuser and non-abuser groups. The contribution of MDR1 polymorphisms to pharmacokinetic variability of antiretroviral therapy was further assessed. RESULTS Genotype assignments based on PCR growth curve, fluorescence melt-curve analysis, and gel electrophoresis of PCR products were in good agreement. Although no significant difference in MDR1 polymorphism distribution was noted between substance users and non-users (G=4.4, G2677T; G=0.6, C3435T), it appeared to be racially dependent with 75% and 92% African Americans having wild type C3435T and G2677T, versus 22% and 26% in Caucasians, respectively. A clear link between G2677T and C3435T was also noted. No relationship was observed in these initial patients between MDR1 genotypes and pharmacokinetic measures. CONCLUSION This method is being incorporated into the TDM program implemented in the pharmacotherapy research center. Clinical Pharmacology & Therapeutics (2005) 79, P67–P67; doi: 10.1016/j.clpt.2005.12.243" @default.
- W2318384586 created "2016-06-24" @default.
- W2318384586 creator A5001380703 @default.
- W2318384586 creator A5012914587 @default.
- W2318384586 creator A5026161672 @default.
- W2318384586 creator A5037196439 @default.
- W2318384586 creator A5055908944 @default.
- W2318384586 creator A5066252006 @default.
- W2318384586 creator A5070552330 @default.
- W2318384586 creator A5071686386 @default.
- W2318384586 creator A5078597872 @default.
- W2318384586 creator A5084232309 @default.
- W2318384586 date "2006-02-01" @default.
- W2318384586 modified "2023-09-25" @default.
- W2318384586 title "PIII-35Detection of MDR1 single nucleotide polymorphisms in HIV-infected substance users and nonusers" @default.
- W2318384586 doi "https://doi.org/10.1016/j.clpt.2005.12.243" @default.
- W2318384586 hasPublicationYear "2006" @default.
- W2318384586 type Work @default.
- W2318384586 sameAs 2318384586 @default.
- W2318384586 citedByCount "0" @default.
- W2318384586 crossrefType "journal-article" @default.
- W2318384586 hasAuthorship W2318384586A5001380703 @default.
- W2318384586 hasAuthorship W2318384586A5012914587 @default.
- W2318384586 hasAuthorship W2318384586A5026161672 @default.
- W2318384586 hasAuthorship W2318384586A5037196439 @default.
- W2318384586 hasAuthorship W2318384586A5055908944 @default.
- W2318384586 hasAuthorship W2318384586A5066252006 @default.
- W2318384586 hasAuthorship W2318384586A5070552330 @default.
- W2318384586 hasAuthorship W2318384586A5071686386 @default.
- W2318384586 hasAuthorship W2318384586A5078597872 @default.
- W2318384586 hasAuthorship W2318384586A5084232309 @default.
- W2318384586 hasConcept C104317684 @default.
- W2318384586 hasConcept C112705442 @default.
- W2318384586 hasConcept C114851261 @default.
- W2318384586 hasConcept C126322002 @default.
- W2318384586 hasConcept C133936738 @default.
- W2318384586 hasConcept C135763542 @default.
- W2318384586 hasConcept C143998085 @default.
- W2318384586 hasConcept C153209595 @default.
- W2318384586 hasConcept C159047783 @default.
- W2318384586 hasConcept C2778707650 @default.
- W2318384586 hasConcept C2780035454 @default.
- W2318384586 hasConcept C2780272996 @default.
- W2318384586 hasConcept C31467283 @default.
- W2318384586 hasConcept C500440147 @default.
- W2318384586 hasConcept C54355233 @default.
- W2318384586 hasConcept C63433958 @default.
- W2318384586 hasConcept C71924100 @default.
- W2318384586 hasConcept C86803240 @default.
- W2318384586 hasConcept C98274493 @default.
- W2318384586 hasConceptScore W2318384586C104317684 @default.
- W2318384586 hasConceptScore W2318384586C112705442 @default.
- W2318384586 hasConceptScore W2318384586C114851261 @default.
- W2318384586 hasConceptScore W2318384586C126322002 @default.
- W2318384586 hasConceptScore W2318384586C133936738 @default.
- W2318384586 hasConceptScore W2318384586C135763542 @default.
- W2318384586 hasConceptScore W2318384586C143998085 @default.
- W2318384586 hasConceptScore W2318384586C153209595 @default.
- W2318384586 hasConceptScore W2318384586C159047783 @default.
- W2318384586 hasConceptScore W2318384586C2778707650 @default.
- W2318384586 hasConceptScore W2318384586C2780035454 @default.
- W2318384586 hasConceptScore W2318384586C2780272996 @default.
- W2318384586 hasConceptScore W2318384586C31467283 @default.
- W2318384586 hasConceptScore W2318384586C500440147 @default.
- W2318384586 hasConceptScore W2318384586C54355233 @default.
- W2318384586 hasConceptScore W2318384586C63433958 @default.
- W2318384586 hasConceptScore W2318384586C71924100 @default.
- W2318384586 hasConceptScore W2318384586C86803240 @default.
- W2318384586 hasConceptScore W2318384586C98274493 @default.
- W2318384586 hasIssue "2" @default.
- W2318384586 hasLocation W23183845861 @default.
- W2318384586 hasOpenAccess W2318384586 @default.
- W2318384586 hasPrimaryLocation W23183845861 @default.
- W2318384586 hasRelatedWork W1549843613 @default.
- W2318384586 hasRelatedWork W188266097 @default.
- W2318384586 hasRelatedWork W2036965660 @default.
- W2318384586 hasRelatedWork W2071861382 @default.
- W2318384586 hasRelatedWork W2080489638 @default.
- W2318384586 hasRelatedWork W2083913321 @default.
- W2318384586 hasRelatedWork W2164332050 @default.
- W2318384586 hasRelatedWork W2567767604 @default.
- W2318384586 hasRelatedWork W2889241014 @default.
- W2318384586 hasRelatedWork W589099824 @default.
- W2318384586 hasVolume "79" @default.
- W2318384586 isParatext "false" @default.
- W2318384586 isRetracted "false" @default.
- W2318384586 magId "2318384586" @default.
- W2318384586 workType "article" @default.