FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318402418> ?p ?o ?g. }

• W2318402418 abstract "Transfer RNA (tRNA) from all organisms on this planet contains modified nucleosides, which are derivatives of the four major nucleosides. tRNA from Escherichia coli/Salmonella enterica serovar Typhimurium contains 33 different modified nucleosides, which are all, except one (Queuosine [Q]), synthesized on an oligonucleotide precursor, which by specific enzymes later matures into tRNA. The structural genes for these enzymes are found in mono- and polycistronic operons, the latter of which have a complex transcription and translation pattern. The synthesis of the tRNA-modifying enzymes is not regulated similarly, and it is not coordinated to that of their substrate, the tRNA. The synthesis of some of them (e.g., several methylated derivatives) is catalyzed by one enzyme, which is position and base specific, whereas synthesis of some has a very complex biosynthetic pathway involving several enzymes (e.g., 2-thiouridines, N 6-cyclicthreonyladenosine [ct6A], and Q). Several of the modified nucleosides are essential for viability (e.g., lysidin, ct6A, 1-methylguanosine), whereas the deficiency of others induces severe growth defects. However, some have no or only a small effect on growth at laboratory conditions. Modified nucleosides that are present in the anticodon loop or stem have a fundamental influence on the efficiency of charging the tRNA, reading cognate codons, and preventing missense and frameshift errors. Those that are present in the body of the tRNA primarily have a stabilizing effect on the tRNA. Thus, the ubiquitous presence of these modified nucleosides plays a pivotal role in the function of the tRNA by their influence on the stability and activity of the tRNA." @default.
• W2318402418 created "2016-06-24" @default.
• W2318402418 creator A5001422328 @default.
• W2318402418 creator A5090225020 @default.
• W2318402418 date "2014-05-09" @default.
• W2318402418 modified "2023-10-03" @default.
• W2318402418 title "Transfer RNA Modification: Presence, Synthesis, and Function" @default.
• W2318402418 cites W1021892364 @default.
• W2318402418 cites W1133902369 @default.
• W2318402418 cites W1479780985 @default.
• W2318402418 cites W1480395323 @default.
• W2318402418 cites W1481100343 @default.
• W2318402418 cites W1482562661 @default.
• W2318402418 cites W1483292430 @default.
• W2318402418 cites W1485008208 @default.
• W2318402418 cites W1485553339 @default.
• W2318402418 cites W1486135496 @default.
• W2318402418 cites W1486961988 @default.
• W2318402418 cites W1490568885 @default.
• W2318402418 cites W1494417233 @default.
• W2318402418 cites W1499272745 @default.
• W2318402418 cites W1501954650 @default.
• W2318402418 cites W1503702533 @default.
• W2318402418 cites W1505447146 @default.
• W2318402418 cites W1506601942 @default.
• W2318402418 cites W1506896046 @default.
• W2318402418 cites W1511418214 @default.
• W2318402418 cites W1512528596 @default.
• W2318402418 cites W1517340766 @default.
• W2318402418 cites W1519739439 @default.
• W2318402418 cites W1520934266 @default.
• W2318402418 cites W1526889047 @default.
• W2318402418 cites W1527006195 @default.
• W2318402418 cites W1527736225 @default.
• W2318402418 cites W1532421291 @default.
• W2318402418 cites W1534961305 @default.
• W2318402418 cites W1540118907 @default.
• W2318402418 cites W1540521265 @default.
• W2318402418 cites W1540585850 @default.
• W2318402418 cites W1540963830 @default.
• W2318402418 cites W1541196086 @default.
• W2318402418 cites W1546767835 @default.
• W2318402418 cites W1551922596 @default.
• W2318402418 cites W1553518074 @default.
• W2318402418 cites W1557540738 @default.
• W2318402418 cites W1561396590 @default.
• W2318402418 cites W1561832177 @default.
• W2318402418 cites W1567897268 @default.
• W2318402418 cites W1568361931 @default.
• W2318402418 cites W1571751680 @default.
• W2318402418 cites W1571926979 @default.
• W2318402418 cites W1573792528 @default.
• W2318402418 cites W1575561658 @default.
• W2318402418 cites W1581318482 @default.
• W2318402418 cites W1583996118 @default.
• W2318402418 cites W1588731527 @default.
• W2318402418 cites W1596767177 @default.
• W2318402418 cites W1597054855 @default.
• W2318402418 cites W1597915137 @default.
• W2318402418 cites W1600354532 @default.
• W2318402418 cites W1600544078 @default.
• W2318402418 cites W1600654702 @default.
• W2318402418 cites W1600905922 @default.
• W2318402418 cites W1602817271 @default.
• W2318402418 cites W1602956564 @default.
• W2318402418 cites W1605039020 @default.
• W2318402418 cites W1608763722 @default.
• W2318402418 cites W1637028605 @default.
• W2318402418 cites W1639542273 @default.
• W2318402418 cites W1647577587 @default.
• W2318402418 cites W1653521447 @default.
• W2318402418 cites W1665716161 @default.
• W2318402418 cites W1672854538 @default.
• W2318402418 cites W1673573808 @default.
• W2318402418 cites W1676201694 @default.
• W2318402418 cites W1676516687 @default.
• W2318402418 cites W1728556152 @default.
• W2318402418 cites W1763928719 @default.
• W2318402418 cites W1771448216 @default.
• W2318402418 cites W1802135738 @default.
• W2318402418 cites W1821823714 @default.
• W2318402418 cites W1827226170 @default.
• W2318402418 cites W1840854609 @default.
• W2318402418 cites W1847098232 @default.
• W2318402418 cites W1850384628 @default.
• W2318402418 cites W1858279107 @default.
• W2318402418 cites W1859271115 @default.
• W2318402418 cites W1865678930 @default.
• W2318402418 cites W1866977876 @default.
• W2318402418 cites W1894856070 @default.
• W2318402418 cites W1902639406 @default.
• W2318402418 cites W1905747143 @default.
• W2318402418 cites W1908700832 @default.
• W2318402418 cites W1916389875 @default.
• W2318402418 cites W1917138181 @default.
• W2318402418 cites W1920218959 @default.
• W2318402418 cites W1930077823 @default.
• W2318402418 cites W1938034723 @default.
• W2318402418 cites W1939409359 @default.
• W2318402418 cites W1940525454 @default.

• next