Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318411993> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2318411993 endingPage "543" @default.
- W2318411993 startingPage "537" @default.
- W2318411993 abstract "Summary Delivering emulsions of anthracycline drugs in Lipiodol, an iodinated poppy-seed oil, via the hepatic artery for the treatment of hepatocellular carcinoma (HCC) has become increasingly popular. However, investigations to determine the extent to which the Lipiodol sequesters the anthracycline in the liver have been limited. Concern has been expressed that such emulsions are not stable and that the anthracycline is, therefore, released rapidly into the circulation. We studied the pharmacokinetics of epirubicin (50 mg m-2) in five patients with nonresectable primary hepatocellular carcinoma after infusion of an epirubicin/Lipiodol emulsion via the hepatic artery. We used a reliable and specific high-performance liquid chromatography assay that allows quantitation of plasma concentrations of epirubicin, epirubicinol, epirubicin glucuronide, and epirubicin aglycone. Although a large interpatient variability in pharmacokinetics was observed, our results were similar to historical data after epirubicin intravenous therapy. Only the results from one patient provided evidence of significant retention of the drug in the liver. It would appear that more stable formulations of epirubicin/Lipiodol are required to increase the efficacy of this form of treatment. We suggest that pharmacokinetic studies should accompany clinical evaluation of emulsions of epirubicin/Lipiodol for the treatment of HCC." @default.
- W2318411993 created "2016-06-24" @default.
- W2318411993 creator A5018463878 @default.
- W2318411993 creator A5026219166 @default.
- W2318411993 creator A5054173917 @default.
- W2318411993 creator A5076399397 @default.
- W2318411993 creator A5084102651 @default.
- W2318411993 date "1996-10-01" @default.
- W2318411993 modified "2023-09-25" @default.
- W2318411993 title "Disposition of Epirubicin After Intraarterial Administration in Lipiodol to Patients with Hepatocellular Carcinoma" @default.
- W2318411993 cites W1964044673 @default.
- W2318411993 cites W1977043849 @default.
- W2318411993 cites W1982171226 @default.
- W2318411993 cites W1994826152 @default.
- W2318411993 cites W2010680051 @default.
- W2318411993 cites W2029510225 @default.
- W2318411993 cites W2039217655 @default.
- W2318411993 cites W2044695745 @default.
- W2318411993 cites W2045789731 @default.
- W2318411993 cites W2056302939 @default.
- W2318411993 cites W2056337361 @default.
- W2318411993 cites W2064232360 @default.
- W2318411993 cites W2064745629 @default.
- W2318411993 cites W2065281115 @default.
- W2318411993 cites W2067219735 @default.
- W2318411993 cites W2074965477 @default.
- W2318411993 cites W2094208100 @default.
- W2318411993 cites W2119615296 @default.
- W2318411993 cites W2158951200 @default.
- W2318411993 doi "https://doi.org/10.1097/00007691-199610000-00003" @default.
- W2318411993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8885116" @default.
- W2318411993 hasPublicationYear "1996" @default.
- W2318411993 type Work @default.
- W2318411993 sameAs 2318411993 @default.
- W2318411993 citedByCount "14" @default.
- W2318411993 countsByYear W23184119932012 @default.
- W2318411993 countsByYear W23184119932013 @default.
- W2318411993 countsByYear W23184119932015 @default.
- W2318411993 countsByYear W23184119932023 @default.
- W2318411993 crossrefType "journal-article" @default.
- W2318411993 hasAuthorship W2318411993A5018463878 @default.
- W2318411993 hasAuthorship W2318411993A5026219166 @default.
- W2318411993 hasAuthorship W2318411993A5054173917 @default.
- W2318411993 hasAuthorship W2318411993A5076399397 @default.
- W2318411993 hasAuthorship W2318411993A5084102651 @default.
- W2318411993 hasConcept C112705442 @default.
- W2318411993 hasConcept C121608353 @default.
- W2318411993 hasConcept C126322002 @default.
- W2318411993 hasConcept C2776694085 @default.
- W2318411993 hasConcept C2776755627 @default.
- W2318411993 hasConcept C2776802502 @default.
- W2318411993 hasConcept C2778019345 @default.
- W2318411993 hasConcept C2778448856 @default.
- W2318411993 hasConcept C2780835546 @default.
- W2318411993 hasConcept C530470458 @default.
- W2318411993 hasConcept C71924100 @default.
- W2318411993 hasConcept C90924648 @default.
- W2318411993 hasConcept C98274493 @default.
- W2318411993 hasConceptScore W2318411993C112705442 @default.
- W2318411993 hasConceptScore W2318411993C121608353 @default.
- W2318411993 hasConceptScore W2318411993C126322002 @default.
- W2318411993 hasConceptScore W2318411993C2776694085 @default.
- W2318411993 hasConceptScore W2318411993C2776755627 @default.
- W2318411993 hasConceptScore W2318411993C2776802502 @default.
- W2318411993 hasConceptScore W2318411993C2778019345 @default.
- W2318411993 hasConceptScore W2318411993C2778448856 @default.
- W2318411993 hasConceptScore W2318411993C2780835546 @default.
- W2318411993 hasConceptScore W2318411993C530470458 @default.
- W2318411993 hasConceptScore W2318411993C71924100 @default.
- W2318411993 hasConceptScore W2318411993C90924648 @default.
- W2318411993 hasConceptScore W2318411993C98274493 @default.
- W2318411993 hasIssue "5" @default.
- W2318411993 hasLocation W23184119931 @default.
- W2318411993 hasLocation W23184119932 @default.
- W2318411993 hasOpenAccess W2318411993 @default.
- W2318411993 hasPrimaryLocation W23184119931 @default.
- W2318411993 hasRelatedWork W1967242904 @default.
- W2318411993 hasRelatedWork W2030163342 @default.
- W2318411993 hasRelatedWork W2078074588 @default.
- W2318411993 hasRelatedWork W2153230751 @default.
- W2318411993 hasRelatedWork W2318411993 @default.
- W2318411993 hasRelatedWork W2358144868 @default.
- W2318411993 hasRelatedWork W2363729718 @default.
- W2318411993 hasRelatedWork W2391739397 @default.
- W2318411993 hasRelatedWork W2745218523 @default.
- W2318411993 hasRelatedWork W4230408363 @default.
- W2318411993 hasVolume "18" @default.
- W2318411993 isParatext "false" @default.
- W2318411993 isRetracted "false" @default.
- W2318411993 magId "2318411993" @default.
- W2318411993 workType "article" @default.