Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318425964> ?p ?o ?g. }
- W2318425964 endingPage "680" @default.
- W2318425964 startingPage "647" @default.
- W2318425964 abstract "In recent years, heparanase has attracted considerable attention as a promising target for innovative pharmacological applications. Heparanase is a multifaceted protein endowed with enzymatic activity, as an endo-β-D-glucuronidase, and nonenzymatic functions. It is responsible for the cleavage of heparan sulfate side chains of proteoglycans, resulting in structural alterations of the extracellular matrix. Heparanase appears to be involved in major human diseases, from the most studied tumors to chronic inflammation, diabetic nephropathy, bone osteolysis, thrombosis and atherosclerosis, in addition to more recent investigation in various rare diseases. The present review provides an overview on heparanase, its biological role, inhibitors and possible clinical applications, covering the latest findings in these areas." @default.
- W2318425964 created "2016-06-24" @default.
- W2318425964 creator A5028382507 @default.
- W2318425964 creator A5037065405 @default.
- W2318425964 creator A5058573191 @default.
- W2318425964 date "2016-04-01" @default.
- W2318425964 modified "2023-10-17" @default.
- W2318425964 title "Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases" @default.
- W2318425964 cites W1469104101 @default.
- W2318425964 cites W1476658428 @default.
- W2318425964 cites W1491748226 @default.
- W2318425964 cites W1513452909 @default.
- W2318425964 cites W1526312778 @default.
- W2318425964 cites W1535606309 @default.
- W2318425964 cites W1537480471 @default.
- W2318425964 cites W1718414737 @default.
- W2318425964 cites W186113943 @default.
- W2318425964 cites W1869562643 @default.
- W2318425964 cites W1869719033 @default.
- W2318425964 cites W1896680896 @default.
- W2318425964 cites W1929379028 @default.
- W2318425964 cites W1935712031 @default.
- W2318425964 cites W1954547860 @default.
- W2318425964 cites W1963805168 @default.
- W2318425964 cites W1964935114 @default.
- W2318425964 cites W1965520866 @default.
- W2318425964 cites W1967205399 @default.
- W2318425964 cites W1968152808 @default.
- W2318425964 cites W1968317675 @default.
- W2318425964 cites W1970072221 @default.
- W2318425964 cites W1970849520 @default.
- W2318425964 cites W1970851962 @default.
- W2318425964 cites W1971939635 @default.
- W2318425964 cites W1972196380 @default.
- W2318425964 cites W1972215168 @default.
- W2318425964 cites W1972420702 @default.
- W2318425964 cites W1972624690 @default.
- W2318425964 cites W1973151213 @default.
- W2318425964 cites W1973350651 @default.
- W2318425964 cites W1973803139 @default.
- W2318425964 cites W1974187431 @default.
- W2318425964 cites W1975475235 @default.
- W2318425964 cites W1980795306 @default.
- W2318425964 cites W1982684154 @default.
- W2318425964 cites W1984019885 @default.
- W2318425964 cites W1985641370 @default.
- W2318425964 cites W1986936841 @default.
- W2318425964 cites W1988373436 @default.
- W2318425964 cites W1988452415 @default.
- W2318425964 cites W1988887339 @default.
- W2318425964 cites W1992120048 @default.
- W2318425964 cites W1994334062 @default.
- W2318425964 cites W1996269830 @default.
- W2318425964 cites W1996795546 @default.
- W2318425964 cites W1997613697 @default.
- W2318425964 cites W1998650790 @default.
- W2318425964 cites W2004105893 @default.
- W2318425964 cites W2004577947 @default.
- W2318425964 cites W2005175992 @default.
- W2318425964 cites W2006458534 @default.
- W2318425964 cites W2008581828 @default.
- W2318425964 cites W2009962397 @default.
- W2318425964 cites W2010101595 @default.
- W2318425964 cites W2010117209 @default.
- W2318425964 cites W2011705594 @default.
- W2318425964 cites W2012767739 @default.
- W2318425964 cites W2013200943 @default.
- W2318425964 cites W2013232219 @default.
- W2318425964 cites W2013716134 @default.
- W2318425964 cites W2014245961 @default.
- W2318425964 cites W2014526176 @default.
- W2318425964 cites W2016050368 @default.
- W2318425964 cites W2017592559 @default.
- W2318425964 cites W2018242510 @default.
- W2318425964 cites W2020098579 @default.
- W2318425964 cites W2020113016 @default.
- W2318425964 cites W2020722562 @default.
- W2318425964 cites W2020866377 @default.
- W2318425964 cites W2021130116 @default.
- W2318425964 cites W2022532273 @default.
- W2318425964 cites W2026523028 @default.
- W2318425964 cites W2027261163 @default.
- W2318425964 cites W2027789202 @default.
- W2318425964 cites W2028477742 @default.
- W2318425964 cites W2033487253 @default.
- W2318425964 cites W2034908043 @default.
- W2318425964 cites W2036633274 @default.
- W2318425964 cites W2036636505 @default.
- W2318425964 cites W2037516225 @default.
- W2318425964 cites W2037813339 @default.
- W2318425964 cites W2039196862 @default.
- W2318425964 cites W2042802733 @default.
- W2318425964 cites W2043255611 @default.
- W2318425964 cites W2043451019 @default.
- W2318425964 cites W2044643945 @default.
- W2318425964 cites W2046931245 @default.
- W2318425964 cites W2047059447 @default.
- W2318425964 cites W2049056185 @default.