Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318449944> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2318449944 endingPage "6" @default.
- W2318449944 startingPage "2562" @default.
- W2318449944 abstract "To research the effects of moschus, borneol, styrax and benzoinum on the structure and function of blood brain barrier in cerebral ischemia-reperfusion injury model rats.Focal middle cerebral artery occlusion (MCAO) was introduced as an in vivo ischemic model in rats. After 2 h MCAO, nylon suture was pulled up 1 cm to give blood reperfusion. After 22 h reperfusion, all animals were decapitated. The ultramicrostructure of blood brain barrier of ischemia hemisphere side in fronto-parietal cortex region by transmission electron microscope, and the content of VEGF and MMP-9 in ischemia side brain tissue were measured by ELISA.In model and solvent group rats, the capillary endothelium cells, astro-glial cells and nerve cells in ischemia hemisphere side in fronto-parietal region were emerged in different degree compared with sham-operated groups, which exhibited tight junction between endothelial cells being opened, basal lamina being dissolved, and permeability increasing, and cellularedema. In borneol (0.2 g x kg(-1)) group rats, the structure of three kinds of cells were nearly normal, which tight junction structure was clear, rough endoplasmic reticulum and polyribosome could be found in cytoplasm. In moschus (66.6 mg x kg(-1)) group rats, the structure of capillary endothelium cells and astrocytes were nearly normal as well as the basal lamina, but the electrons in neurons was maldistribution. In styrax (1.332 g x kg(-1)) group rats, astrocytes were nearly normal, while capillary endothelial cells and neurons exhibited oedema in different degrees. And the basal lamina was discontinuous, augmentation of cell spaces in endothelial cells increased the permeability, some endoplasmic reticulum broadened and ribosome ablated. In benzoinum (1.0 g x kg(-1)) group rats, oedema of capillary endothelial cells and astrocytes was significant, basal lamina broke. Meanwhile endoplasmic reticulum broadened as vacuole, the number of ribosome in rough endoplasmic reticulum decreased, crista mitochondriales in some neurons disappeared as vacuole which hint oedema happened. Results also showed that borneol decrease the level of VEGF in ischemia side brain tissue significantly, while has little influence on the level of MMP-9. Moschus showed the tendency to decrease the level of VEGF and MMP-9 in ischemia side brain tissue.Aromatic resuscitation drugs showed the protection effect on blood brain barrier in cerebral ischemia-reperfusion injury rats, which the protection effect of moschus and borneol were better than that of styrax and benzoinum. The mechanism of protection effect maybe related to decrease the level of VEGF and MMP-9." @default.
- W2318449944 created "2016-06-24" @default.
- W2318449944 creator A5032764121 @default.
- W2318449944 creator A5034488243 @default.
- W2318449944 creator A5037771962 @default.
- W2318449944 creator A5039946115 @default.
- W2318449944 creator A5060787321 @default.
- W2318449944 creator A5083325410 @default.
- W2318449944 creator A5091445235 @default.
- W2318449944 date "2011-09-01" @default.
- W2318449944 modified "2023-09-23" @default.
- W2318449944 title "[Effects of aromatic resuscitation drugs on blood brain barrier in cerebral ischemia-reperfusion injury model rats]." @default.
- W2318449944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22256767" @default.
- W2318449944 hasPublicationYear "2011" @default.
- W2318449944 type Work @default.
- W2318449944 sameAs 2318449944 @default.
- W2318449944 citedByCount "7" @default.
- W2318449944 countsByYear W23184499442015 @default.
- W2318449944 countsByYear W23184499442017 @default.
- W2318449944 countsByYear W23184499442019 @default.
- W2318449944 countsByYear W23184499442022 @default.
- W2318449944 crossrefType "journal-article" @default.
- W2318449944 hasAuthorship W2318449944A5032764121 @default.
- W2318449944 hasAuthorship W2318449944A5034488243 @default.
- W2318449944 hasAuthorship W2318449944A5037771962 @default.
- W2318449944 hasAuthorship W2318449944A5039946115 @default.
- W2318449944 hasAuthorship W2318449944A5060787321 @default.
- W2318449944 hasAuthorship W2318449944A5083325410 @default.
- W2318449944 hasAuthorship W2318449944A5091445235 @default.
- W2318449944 hasConcept C105702510 @default.
- W2318449944 hasConcept C126322002 @default.
- W2318449944 hasConcept C142724271 @default.
- W2318449944 hasConcept C158617107 @default.
- W2318449944 hasConcept C177779419 @default.
- W2318449944 hasConcept C185592680 @default.
- W2318449944 hasConcept C2776992346 @default.
- W2318449944 hasConcept C2777831001 @default.
- W2318449944 hasConcept C2778402981 @default.
- W2318449944 hasConcept C2779333224 @default.
- W2318449944 hasConcept C2780114680 @default.
- W2318449944 hasConcept C529278444 @default.
- W2318449944 hasConcept C541997718 @default.
- W2318449944 hasConcept C55493867 @default.
- W2318449944 hasConcept C71924100 @default.
- W2318449944 hasConcept C87555872 @default.
- W2318449944 hasConceptScore W2318449944C105702510 @default.
- W2318449944 hasConceptScore W2318449944C126322002 @default.
- W2318449944 hasConceptScore W2318449944C142724271 @default.
- W2318449944 hasConceptScore W2318449944C158617107 @default.
- W2318449944 hasConceptScore W2318449944C177779419 @default.
- W2318449944 hasConceptScore W2318449944C185592680 @default.
- W2318449944 hasConceptScore W2318449944C2776992346 @default.
- W2318449944 hasConceptScore W2318449944C2777831001 @default.
- W2318449944 hasConceptScore W2318449944C2778402981 @default.
- W2318449944 hasConceptScore W2318449944C2779333224 @default.
- W2318449944 hasConceptScore W2318449944C2780114680 @default.
- W2318449944 hasConceptScore W2318449944C529278444 @default.
- W2318449944 hasConceptScore W2318449944C541997718 @default.
- W2318449944 hasConceptScore W2318449944C55493867 @default.
- W2318449944 hasConceptScore W2318449944C71924100 @default.
- W2318449944 hasConceptScore W2318449944C87555872 @default.
- W2318449944 hasIssue "18" @default.
- W2318449944 hasLocation W23184499441 @default.
- W2318449944 hasOpenAccess W2318449944 @default.
- W2318449944 hasPrimaryLocation W23184499441 @default.
- W2318449944 hasRelatedWork W2005675003 @default.
- W2318449944 hasRelatedWork W2013499417 @default.
- W2318449944 hasRelatedWork W2021547629 @default.
- W2318449944 hasRelatedWork W2059688779 @default.
- W2318449944 hasRelatedWork W2065107824 @default.
- W2318449944 hasRelatedWork W2070940233 @default.
- W2318449944 hasRelatedWork W2180744905 @default.
- W2318449944 hasRelatedWork W2285567404 @default.
- W2318449944 hasRelatedWork W2313999489 @default.
- W2318449944 hasRelatedWork W2362032185 @default.
- W2318449944 hasRelatedWork W2363914761 @default.
- W2318449944 hasRelatedWork W2390046502 @default.
- W2318449944 hasRelatedWork W2391444348 @default.
- W2318449944 hasRelatedWork W2592232703 @default.
- W2318449944 hasRelatedWork W2597741399 @default.
- W2318449944 hasRelatedWork W2604283284 @default.
- W2318449944 hasRelatedWork W3025237601 @default.
- W2318449944 hasRelatedWork W3030404859 @default.
- W2318449944 hasRelatedWork W3165524283 @default.
- W2318449944 hasRelatedWork W94932582 @default.
- W2318449944 hasVolume "36" @default.
- W2318449944 isParatext "false" @default.
- W2318449944 isRetracted "false" @default.
- W2318449944 magId "2318449944" @default.
- W2318449944 workType "article" @default.