FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318453870> ?p ?o ?g. }

• W2318453870 endingPage "835" @default.
• W2318453870 startingPage "827" @default.
• W2318453870 abstract "An antitumor peptide from Musca domestica pupae (MATP) was seen to inhibit proliferation and induce apoptosis in cancer cells in our previous investigation. However, the molecular mechanisms involved in MATP-induced apoptosis are still uncharacterized in the human liver cancer cell line HepG2. The present study was undertaken to elucidate the signaling events in MATP-induced apoptosis of HepG2 cells. In this study, the sustained activation of phosphorylated c-Jun N-terminal kinase (JNK) and the obvious inactivation of phosphorylated AktSer473, which prevented IκBα from degeneration, were induced by MATP. Simultaneously, the apoptosis induced by MATP was reversed by SP600125 (a JNK inhibitor) whereas it was aggravated by LY294002 (an Akt inhibitor). These results proved that JNK and Akt independently participated in the apoptosis of HepG2 cells, which were treated with MATP. Moreover, the activation of phosphorylated JNK together with the inactivation of phosphorylated AktSer473 restrained nuclear factor-κB (NF-κB p65) from entering the nucleus. The apoptosis induced by MATP was increased by pyrrolidine dithiocarbamate (NF-κB p65 inhibitor) and the restriction of NF-κB p65 from entering the nucleus induced the decrease of Bcl-2. Simultaneously, MATP induced the increase of Bax, but this mechanism did not depend on the decrease of NF-κB p65 in the nucleus. The release of cytochrome c from the mitochondria, which intensified the expression of caspase-9 and caspase-3, was enhanced by the increase in Bax-to-Bcl-2 expression ratio. The apoptosis of HepG2 cells was induced ultimately by the increase in caspase-3. Taken together, these findings suggest that MATP-induced apoptosis through a JNK-mediated and Akt-mediated NF-κB pathway." @default.
• W2318453870 created "2016-06-24" @default.
• W2318453870 creator A5020619790 @default.
• W2318453870 creator A5030376340 @default.
• W2318453870 creator A5047849729 @default.
• W2318453870 creator A5055924995 @default.
• W2318453870 creator A5066167691 @default.
• W2318453870 creator A5067044183 @default.
• W2318453870 creator A5072153856 @default.
• W2318453870 date "2012-09-01" @default.
• W2318453870 modified "2023-10-16" @default.
• W2318453870 title "An antitumor peptide from Musca domestica pupae (MATP) induces apoptosis in HepG2 cells through a JNK-mediated and Akt-mediated NF-κB pathway" @default.
• W2318453870 cites W1617532721 @default.
• W2318453870 cites W1807380980 @default.
• W2318453870 cites W1973010816 @default.
• W2318453870 cites W1976190079 @default.
• W2318453870 cites W1981303092 @default.
• W2318453870 cites W1984535581 @default.
• W2318453870 cites W1986060421 @default.
• W2318453870 cites W1993153738 @default.
• W2318453870 cites W2002408013 @default.
• W2318453870 cites W2007192646 @default.
• W2318453870 cites W2015753524 @default.
• W2318453870 cites W2024306318 @default.
• W2318453870 cites W2032531389 @default.
• W2318453870 cites W2032896433 @default.
• W2318453870 cites W2035154049 @default.
• W2318453870 cites W2035967893 @default.
• W2318453870 cites W2036981601 @default.
• W2318453870 cites W2055155126 @default.
• W2318453870 cites W2061690334 @default.
• W2318453870 cites W2062489468 @default.
• W2318453870 cites W2063595818 @default.
• W2318453870 cites W2064711537 @default.
• W2318453870 cites W2066868766 @default.
• W2318453870 cites W2072252062 @default.
• W2318453870 cites W2076485183 @default.
• W2318453870 cites W2106877484 @default.
• W2318453870 cites W2111923037 @default.
• W2318453870 cites W2115207474 @default.
• W2318453870 cites W2125570177 @default.
• W2318453870 cites W2131116203 @default.
• W2318453870 cites W2132478963 @default.
• W2318453870 cites W2137428505 @default.
• W2318453870 cites W2140584424 @default.
• W2318453870 cites W2147921405 @default.
• W2318453870 cites W2171796045 @default.
• W2318453870 cites W2388163742 @default.
• W2318453870 cites W2999065750 @default.
• W2318453870 cites W4379365691 @default.
• W2318453870 doi "https://doi.org/10.1097/cad.0b013e32835455f1" @default.
• W2318453870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22824823" @default.
• W2318453870 hasPublicationYear "2012" @default.
• W2318453870 type Work @default.
• W2318453870 sameAs 2318453870 @default.
• W2318453870 citedByCount "6" @default.
• W2318453870 countsByYear W23184538702015 @default.
• W2318453870 countsByYear W23184538702016 @default.
• W2318453870 countsByYear W23184538702017 @default.
• W2318453870 countsByYear W23184538702019 @default.
• W2318453870 countsByYear W23184538702023 @default.
• W2318453870 crossrefType "journal-article" @default.
• W2318453870 hasAuthorship W2318453870A5020619790 @default.
• W2318453870 hasAuthorship W2318453870A5030376340 @default.
• W2318453870 hasAuthorship W2318453870A5047849729 @default.
• W2318453870 hasAuthorship W2318453870A5055924995 @default.
• W2318453870 hasAuthorship W2318453870A5066167691 @default.
• W2318453870 hasAuthorship W2318453870A5067044183 @default.
• W2318453870 hasAuthorship W2318453870A5072153856 @default.
• W2318453870 hasConcept C11960822 @default.
• W2318453870 hasConcept C153911025 @default.
• W2318453870 hasConcept C184235292 @default.
• W2318453870 hasConcept C185592680 @default.
• W2318453870 hasConcept C190283241 @default.
• W2318453870 hasConcept C2776912716 @default.
• W2318453870 hasConcept C2777730290 @default.
• W2318453870 hasConcept C2780983412 @default.
• W2318453870 hasConcept C29311851 @default.
• W2318453870 hasConcept C55493867 @default.
• W2318453870 hasConcept C62478195 @default.
• W2318453870 hasConcept C75217442 @default.
• W2318453870 hasConcept C86803240 @default.
• W2318453870 hasConcept C95444343 @default.
• W2318453870 hasConceptScore W2318453870C11960822 @default.
• W2318453870 hasConceptScore W2318453870C153911025 @default.
• W2318453870 hasConceptScore W2318453870C184235292 @default.
• W2318453870 hasConceptScore W2318453870C185592680 @default.
• W2318453870 hasConceptScore W2318453870C190283241 @default.
• W2318453870 hasConceptScore W2318453870C2776912716 @default.
• W2318453870 hasConceptScore W2318453870C2777730290 @default.
• W2318453870 hasConceptScore W2318453870C2780983412 @default.
• W2318453870 hasConceptScore W2318453870C29311851 @default.
• W2318453870 hasConceptScore W2318453870C55493867 @default.
• W2318453870 hasConceptScore W2318453870C62478195 @default.
• W2318453870 hasConceptScore W2318453870C75217442 @default.
• W2318453870 hasConceptScore W2318453870C86803240 @default.
• W2318453870 hasConceptScore W2318453870C95444343 @default.
• W2318453870 hasIssue "8" @default.

• next