FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318466421> ?p ?o ?g. }

• W2318466421 endingPage "218" @default.
• W2318466421 startingPage "215" @default.
• W2318466421 abstract "Ibogaine is a plant alkaloid used as anti-addiction drug in dozens of alternative medicine clinics worldwide. Recently, alarming reports of life-threatening cardiac arrhythmias and cases of sudden death associated with the ingestion of ibogaine have accumulated. Using whole-cell patch clamp recordings, we assessed the effects of ibogaine and its main metabolite noribogaine on action potentials in human ventricular-like cardiomyocytes derived from induced pluripotent stem cells. Therapeutic concentrations of ibogaine and its long-lived active metabolite noribogaine significantly retarded action potential repolarization in human cardiomyocytes. These findings represent the first experimental proof that ibogaine application entails a cardiac arrhythmia risk for humans. In addition, they explain the clinically observed delayed incidence of cardiac adverse events several days after ibogaine intake. We conclude that therapeutic concentrations of ibogaine retard action potential repolarization in the human heart. This may give rise to a prolongation of the QT interval in the electrocardiogram and cardiac arrhythmias." @default.
• W2318466421 created "2016-06-24" @default.
• W2318466421 creator A5029101014 @default.
• W2318466421 creator A5039231830 @default.
• W2318466421 creator A5078768057 @default.
• W2318466421 creator A5084073291 @default.
• W2318466421 creator A5085397541 @default.
• W2318466421 date "2016-03-28" @default.
• W2318466421 modified "2023-09-27" @default.
• W2318466421 title "Anti-addiction Drug Ibogaine Prolongs the Action Potential in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes" @default.
• W2318466421 cites W1525003375 @default.
• W2318466421 cites W1583756083 @default.
• W2318466421 cites W1607733577 @default.
• W2318466421 cites W1792210707 @default.
• W2318466421 cites W1948723120 @default.
• W2318466421 cites W1969580202 @default.
• W2318466421 cites W1971381195 @default.
• W2318466421 cites W1996442587 @default.
• W2318466421 cites W2014858922 @default.
• W2318466421 cites W2020659752 @default.
• W2318466421 cites W2026484120 @default.
• W2318466421 cites W2038460090 @default.
• W2318466421 cites W2084204788 @default.
• W2318466421 cites W2086909699 @default.
• W2318466421 cites W2093986323 @default.
• W2318466421 cites W2101160208 @default.
• W2318466421 cites W2113927644 @default.
• W2318466421 cites W2128808302 @default.
• W2318466421 cites W2132500168 @default.
• W2318466421 cites W2134194840 @default.
• W2318466421 cites W2134304898 @default.
• W2318466421 cites W2198838528 @default.
• W2318466421 cites W4320800338 @default.
• W2318466421 doi "https://doi.org/10.1007/s12012-016-9366-y" @default.
• W2318466421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5334404" @default.
• W2318466421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27020671" @default.
• W2318466421 hasPublicationYear "2016" @default.
• W2318466421 type Work @default.
• W2318466421 sameAs 2318466421 @default.
• W2318466421 citedByCount "4" @default.
• W2318466421 countsByYear W23184664212018 @default.
• W2318466421 countsByYear W23184664212021 @default.
• W2318466421 countsByYear W23184664212023 @default.
• W2318466421 crossrefType "journal-article" @default.
• W2318466421 hasAuthorship W2318466421A5029101014 @default.
• W2318466421 hasAuthorship W2318466421A5039231830 @default.
• W2318466421 hasAuthorship W2318466421A5078768057 @default.
• W2318466421 hasAuthorship W2318466421A5084073291 @default.
• W2318466421 hasAuthorship W2318466421A5085397541 @default.
• W2318466421 hasBestOaLocation W23184664211 @default.
• W2318466421 hasConcept C104317684 @default.
• W2318466421 hasConcept C107459253 @default.
• W2318466421 hasConcept C118441451 @default.
• W2318466421 hasConcept C126322002 @default.
• W2318466421 hasConcept C145103041 @default.
• W2318466421 hasConcept C146403970 @default.
• W2318466421 hasConcept C185263204 @default.
• W2318466421 hasConcept C185592680 @default.
• W2318466421 hasConcept C2777477808 @default.
• W2318466421 hasConcept C2779703243 @default.
• W2318466421 hasConcept C2780035454 @default.
• W2318466421 hasConcept C42219234 @default.
• W2318466421 hasConcept C55493867 @default.
• W2318466421 hasConcept C71924100 @default.
• W2318466421 hasConcept C79743260 @default.
• W2318466421 hasConcept C98274493 @default.
• W2318466421 hasConceptScore W2318466421C104317684 @default.
• W2318466421 hasConceptScore W2318466421C107459253 @default.
• W2318466421 hasConceptScore W2318466421C118441451 @default.
• W2318466421 hasConceptScore W2318466421C126322002 @default.
• W2318466421 hasConceptScore W2318466421C145103041 @default.
• W2318466421 hasConceptScore W2318466421C146403970 @default.
• W2318466421 hasConceptScore W2318466421C185263204 @default.
• W2318466421 hasConceptScore W2318466421C185592680 @default.
• W2318466421 hasConceptScore W2318466421C2777477808 @default.
• W2318466421 hasConceptScore W2318466421C2779703243 @default.
• W2318466421 hasConceptScore W2318466421C2780035454 @default.
• W2318466421 hasConceptScore W2318466421C42219234 @default.
• W2318466421 hasConceptScore W2318466421C55493867 @default.
• W2318466421 hasConceptScore W2318466421C71924100 @default.
• W2318466421 hasConceptScore W2318466421C79743260 @default.
• W2318466421 hasConceptScore W2318466421C98274493 @default.
• W2318466421 hasFunder F4320321181 @default.
• W2318466421 hasIssue "2" @default.
• W2318466421 hasLocation W23184664211 @default.
• W2318466421 hasLocation W23184664212 @default.
• W2318466421 hasLocation W23184664213 @default.
• W2318466421 hasLocation W23184664214 @default.
• W2318466421 hasOpenAccess W2318466421 @default.
• W2318466421 hasPrimaryLocation W23184664211 @default.
• W2318466421 hasRelatedWork W1584909281 @default.
• W2318466421 hasRelatedWork W2060461813 @default.
• W2318466421 hasRelatedWork W2088483457 @default.
• W2318466421 hasRelatedWork W2108736561 @default.
• W2318466421 hasRelatedWork W2120345341 @default.
• W2318466421 hasRelatedWork W2132249803 @default.
• W2318466421 hasRelatedWork W2403303500 @default.
• W2318466421 hasRelatedWork W2434468260 @default.

• next