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- W2318488319 abstract "Purpose: The effect of chronic pressure overload on the diastolic function of the right ventricle (RV) has not been well studied in humans. We explored the relationship between invasive measures of RV diastolic function and RV pressure across a range of patients with and without pulmonary hypertension. Methods: Eighteen patients undergoing diagnostic right heart catheterisation were studied. Six patients had left ventricular diastolic dysfunction (LVDD), six had scleroderma, two had LVDD and scleroderma, two had idiopathic pulmonary arterial hypertension and two patients were found to be normal after investigation. RV pressure was measured invasively by a Radi PressureWire sampling at 100 Hz. Afterload was measured by peak RV systolic pressure (RVSP). Diastolic function parameters of minimum RV diastolic pressure (minRVDP) and RV (dP/dt)min and RV end diastolic pressure (RVEDP) were derived. RV tau was calculated using the method of Weiss. All measurements were averaged over five cardiac cycles. Results:Tabled 1Parameter (range)RVSP (18.4–69.3 mmHg)minRVDP (−5.9 to 10.2 mmHg)RVEDP (−2.5 to 15.2 mmHg)RV tau (9–80 ms)r = 0.32p = nsr = 0.91p < 0.0001r = 0.94p < 0.0001RV (dP/dt)min (−200 to −856 mmHg/s)r = −0.89p < 0.0001r = −0.15p = nsr = −0.12p = ns Open table in a new tab RV tau was strongly associated with minRVDP and RVEDP but not with RVSP. RV (dP/dt)min was strongly correlated with RVSP but not minRVDP or RVEDP. Conclusion: RV tau is an afterload independent measure of RV relaxation, while RV (dP/dt)min is strongly inversely associated with peak RV systolic pressure. Early RV relaxation as measured by RV tau is an important determinant of RVEDP as well as minimum RV diastolic pressure." @default.
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- W2318488319 date "2012-01-01" @default.
- W2318488319 modified "2023-10-15" @default.
- W2318488319 title "Right Ventricular Tau is an Important Determinant of Right Ventricular End Diastolic Pressure" @default.
- W2318488319 doi "https://doi.org/10.1016/j.hlc.2012.05.160" @default.
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