FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318499079> ?p ?o ?g. }

• W2318499079 endingPage "1064" @default.
• W2318499079 startingPage "1038" @default.
• W2318499079 abstract "The actual cause and the biochemical changes occurring in chronic inflammation, especially chronic paranasal sinusitis have long remained to be clarified by rhinologic clinicians. The author has tried, as the first step in their elucidation, to separate acid mucopolysaccharides (AMP), which had been considered to have a close connection with inflammation, from the maxillary sinal mucous membrane. Membranes amounting to 800 samples obtained from the operation room were classified as normal, edematous, suppurative and fibrous type according to macroscopic and histological observation and stored separately in acetone. Ten to thirty samples of the mucous membrane of the maxillary sinuse were the subject of each experiment. After the removal of fat and water by acetone, the membranes were dried in vacuum and their dry wei- ght was estimated. Then they were soaked in water, ground and digested with pepsin and trypsin. The crude mucopolysaccharide solution obtained was treated with chloroformamyl alcohol mixture, followed by adsorption to Kaolin and Lloyd reagent in order to eliminate proteins, polypeptide and other impurities, which might have been produced during the digestion. The purified polysaccharide was subjected to fractional precipitation by ethanol in the presence of calcium acetate, and identified by chemical and infrared spectroscopic analyses. The results obtained were as follows : Chondroitin sulfate (ChS) was the main com- ponent of AMP in the paranasal mucosa. In the normal membrane, the total amount of ChS was remarkably small and the ChS present was predominantly in type B. In the case of fib. rous type of the membrane, the total amount of ChS increased and the pattern also changed, that is the amount of ChS-C became largest. This tendency towards an increasing ratio of ChS-C was observed more distinctively in the edematous and the suppurative type. This increase of ChS-C in chronic sinusitis suggested that the activities of the enzyme systems which participate in the synthesis of these polysaccharides may be promoted. Changes of enzyme activity in these systems, especially in relation to the sulfurylation steps, seemed to be more or less correlated with the state of the inflamed membrane. In the next step of the research, attention was directed to the activities of chondroitin sulfotransferase and PAPS-synthesizing system. Regarding the sulfotransferase activity, no significant difference between the normal membrane and the pathological one was demonstrated. In the PAPS-sy nthesizing system, however, remarkable changes of enzyme activity were proven. From the results described above, the etiology and the mechanism of becoming chronic inflammation of the disease were considered to be an abnormally raised activity of AMP synthetic enzymes accompanied by the described change in the pattern of the products." @default.
• W2318499079 created "2016-06-24" @default.
• W2318499079 creator A5080401061 @default.
• W2318499079 date "1966-01-01" @default.
• W2318499079 modified "2023-10-14" @default.
• W2318499079 title "BIOCHEMICAL STUDIES ON ACID MUCOPOLYSACCHARIDES IN PARANASAL MUCOUS MEMBRANE IN CHRONIC SINUSITIS" @default.
• W2318499079 cites W142937375 @default.
• W2318499079 cites W1617779852 @default.
• W2318499079 cites W1665229127 @default.
• W2318499079 cites W188844626 @default.
• W2318499079 cites W1984701521 @default.
• W2318499079 cites W2060477811 @default.
• W2318499079 cites W2062833027 @default.
• W2318499079 cites W2063834453 @default.
• W2318499079 cites W2075381067 @default.
• W2318499079 cites W2122162251 @default.
• W2318499079 cites W2129428759 @default.
• W2318499079 cites W2149142772 @default.
• W2318499079 cites W2229299670 @default.
• W2318499079 cites W2239728382 @default.
• W2318499079 cites W2320551391 @default.
• W2318499079 cites W596700216 @default.
• W2318499079 doi "https://doi.org/10.3950/jibiinkoka.69.5_1038" @default.
• W2318499079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4225934" @default.
• W2318499079 hasPublicationYear "1966" @default.
• W2318499079 type Work @default.
• W2318499079 sameAs 2318499079 @default.
• W2318499079 citedByCount "1" @default.
• W2318499079 crossrefType "journal-article" @default.
• W2318499079 hasAuthorship W2318499079A5080401061 @default.
• W2318499079 hasBestOaLocation W23184990791 @default.
• W2318499079 hasConcept C142724271 @default.
• W2318499079 hasConcept C153074725 @default.
• W2318499079 hasConcept C181199279 @default.
• W2318499079 hasConcept C185592680 @default.
• W2318499079 hasConcept C2776708817 @default.
• W2318499079 hasConcept C2779890267 @default.
• W2318499079 hasConcept C2780340462 @default.
• W2318499079 hasConcept C2781213060 @default.
• W2318499079 hasConcept C41625074 @default.
• W2318499079 hasConcept C43617362 @default.
• W2318499079 hasConcept C55493867 @default.
• W2318499079 hasConcept C71924100 @default.
• W2318499079 hasConcept C86803240 @default.
• W2318499079 hasConcept C89423630 @default.
• W2318499079 hasConceptScore W2318499079C142724271 @default.
• W2318499079 hasConceptScore W2318499079C153074725 @default.
• W2318499079 hasConceptScore W2318499079C181199279 @default.
• W2318499079 hasConceptScore W2318499079C185592680 @default.
• W2318499079 hasConceptScore W2318499079C2776708817 @default.
• W2318499079 hasConceptScore W2318499079C2779890267 @default.
• W2318499079 hasConceptScore W2318499079C2780340462 @default.
• W2318499079 hasConceptScore W2318499079C2781213060 @default.
• W2318499079 hasConceptScore W2318499079C41625074 @default.
• W2318499079 hasConceptScore W2318499079C43617362 @default.
• W2318499079 hasConceptScore W2318499079C55493867 @default.
• W2318499079 hasConceptScore W2318499079C71924100 @default.
• W2318499079 hasConceptScore W2318499079C86803240 @default.
• W2318499079 hasConceptScore W2318499079C89423630 @default.
• W2318499079 hasIssue "5" @default.
• W2318499079 hasLocation W23184990791 @default.
• W2318499079 hasLocation W23184990792 @default.
• W2318499079 hasOpenAccess W2318499079 @default.
• W2318499079 hasPrimaryLocation W23184990791 @default.
• W2318499079 hasRelatedWork W1595501884 @default.
• W2318499079 hasRelatedWork W1995695198 @default.
• W2318499079 hasRelatedWork W1998509743 @default.
• W2318499079 hasRelatedWork W2005864037 @default.
• W2318499079 hasRelatedWork W2020823886 @default.
• W2318499079 hasRelatedWork W2023039516 @default.
• W2318499079 hasRelatedWork W2062109496 @default.
• W2318499079 hasRelatedWork W2067981983 @default.
• W2318499079 hasRelatedWork W2312610724 @default.
• W2318499079 hasRelatedWork W254340394 @default.
• W2318499079 hasVolume "69" @default.
• W2318499079 isParatext "false" @default.
• W2318499079 isRetracted "false" @default.
• W2318499079 magId "2318499079" @default.
• W2318499079 workType "article" @default.