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- W2318508770 abstract "SummaryExperiments in rats are described in which the effect of gradually increasing liver damage upon the action of Dicumarol was studied. Injections of carbon tetrachloride which do not significantly influence the prothrombin level greatly sensitize rats to Dicumarol. Bilateral nephrectomy results in a prolonged and increased effect of this drug. These findings indicate the necessity of care in the administration of this drug to patients having even a mild degree of liver damage or suffering from impairment of the kidney function." @default.
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- W2318508770 date "1943-04-01" @default.
- W2318508770 modified "2023-09-27" @default.
- W2318508770 title "Dicumarol (3,3'-Methylene-Bis-(4-Hydroxy-Coumarin)) in Rats with Impaired Liver or Kidney Function." @default.
- W2318508770 doi "https://doi.org/10.3181/00379727-52-14154" @default.
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