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• W2318517963 abstract "Chronic obstructive pulmonary disease (COPD) affects over 10 million Americans.1 This complex disorder demonstrates many different presentations in a wide variety of patients, and results from a combination of environmental exposures and genetic risk factors. Smoking alone does not result in COPD: not all smokers develop COPD and lung function decline among smokers is highly variable. There is growing evidence for genetic risk factors for COPD: early familial aggregation and linkage analysis studies strongly suggested genetic contributions to COPD, and recent genome-wide association studies have identified several genomic regions that are clearly related to COPD susceptibility. However, despite recent advances in COPD genetics, much of the heritability of COPD remains unexplained, and functional studies are only beginning to elucidate a role for the genetic associations that have been identified. Despite this, the future is bright for understanding the genetics of COPD. Improvements in COPD phenotyping, collaborations among COPD study cohorts, and novel integrative approaches to identifying genetic markers all promise to unravel much of this missing heritability and ultimately lead to improvements in our understanding of COPD susceptibility and treatment." @default.
• W2318517963 created "2016-06-24" @default.
• W2318517963 creator A5035524361 @default.
• W2318517963 creator A5045980264 @default.
• W2318517963 date "2014-01-01" @default.
• W2318517963 modified "2023-10-12" @default.
• W2318517963 title "Chronic Obstructive Pulmonary Disease Genetics: A Review of the Past and a Look Into the Future" @default.
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• W2318517963 doi "https://doi.org/10.15326/jcopdf.1.1.2014.0120" @default.
• W2318517963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5559139" @default.
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