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• W2318551726 endingPage "666" @default.
• W2318551726 startingPage "657" @default.
• W2318551726 abstract "The phosphatase and tensin homolog (PTEN) gene plays a crucial role in signal transduction by negatively regulating the PI3K signaling pathway. It is the most frequent mutated gene in many human-related cancers. Considering its critical role, a functional analysis of missense mutations of PTEN gene was undertaken in this study. Thirty five nonsynonymous single nucleotide polymorphisms (nsSNPs) within the coding region of the PTEN gene were selected for our in silico investigation, and five nsSNPs (G129E, C124R, D252G, H61D, and R130G) were found to be deleterious based on combinatorial predictions of different computational tools. Moreover, molecular dynamics (MD) simulation was performed to investigate the conformational variation between native and all the five mutant PTEN proteins having predicted deleterious nsSNPs. The results of MD simulation of all mutant models illustrated variation in structural attributes such as root-mean-square deviation, root-mean-square fluctuation, radius of gyration, and total energy; which depicts the structural stability of PTEN protein. Furthermore, mutant PTEN protein structures also showed a significant variation in the solvent accessible surface area and hydrogen bond frequencies from the native PTEN structure. In conclusion, results of this study have established the deleterious effect of the all the five predicted nsSNPs on the PTEN protein structure. Thus, results of the current study can pave a new platform to sort out nsSNPs that can be undertaken for the confirmation of their phenotype and their correlation with diseased status in case of control studies." @default.
• W2318551726 created "2016-06-24" @default.
• W2318551726 creator A5065326134 @default.
• W2318551726 creator A5069875882 @default.
• W2318551726 creator A5082313967 @default.
• W2318551726 creator A5090956355 @default.
• W2318551726 date "2017-08-23" @default.
• W2318551726 modified "2023-10-01" @default.
• W2318551726 title "Prediction of functionally significant single nucleotide polymorphisms in<i>PTEN</i>tumor suppressor gene: An<i>in silico</i>approach" @default.
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• W2318551726 cites W1976499671 @default.
• W2318551726 cites W1980740976 @default.
• W2318551726 cites W1981769964 @default.
• W2318551726 cites W1984192295 @default.
• W2318551726 cites W1986191025 @default.
• W2318551726 cites W1988252316 @default.
• W2318551726 cites W1988690429 @default.
• W2318551726 cites W1989860750 @default.
• W2318551726 cites W1994983243 @default.
• W2318551726 cites W1995648971 @default.
• W2318551726 cites W2001353893 @default.
• W2318551726 cites W2004306990 @default.
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• W2318551726 doi "https://doi.org/10.1002/bab.1483" @default.
• W2318551726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26800850" @default.
• W2318551726 hasPublicationYear "2017" @default.
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