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• W2318552693 startingPage "129" @default.
• W2318552693 abstract "SLC41A1 (solute carrier family 41, member A1) is a recently described vertebrate member of the MgtE family of Mg2+ transporters. Although MgtE transporters are found in both prokaryotic and eukaryotic organisms, and are highly conserved, little is known about the regulation of their Mg2+ transport function. In the present study, we have shown that endogenous SLC41A1 transporter expression is post-transcriptionally regulated by extracellular Mg2+ in TRPM7 (transient receptor potential cation channel, subfamily M, member 7)-deficient cells, suggesting that SLC41A1 transporters underlie a novel plasma membrane Mg2+ transport function. Consistent with this conclusion, structure–function analyses of heterologous SLC41A1 transporter expression demonstrate that SLC41A1 transporters exhibit the same plasma membrane orientation as homologous bacterial MgtE proteins, are capable of complementing growth of TRPM7-deficient cells only when the Mg2+ transporting pore is intact, and require an N-terminal cytoplasmic domain for Mg2+-dependent regulation of lysosomal degradation and surface expression. Taken together, our results indicate that SLC41A1 proteins are a central component of vertebrate Mg2+ transport systems, and that their Mg2+ transport function is regulated primarily through an endosomal recycling mechanism involving the SLC41A1 N-terminal cytoplasmic domain." @default.
• W2318552693 created "2016-06-24" @default.
• W2318552693 creator A5060196939 @default.
• W2318552693 creator A5063194527 @default.
• W2318552693 creator A5063879916 @default.
• W2318552693 creator A5081347224 @default.
• W2318552693 date "2011-09-14" @default.
• W2318552693 modified "2023-10-07" @default.
• W2318552693 title "SLC41A1 Mg2+ transport is regulated via Mg2+-dependent endosomal recycling through its N-terminal cytoplasmic domain" @default.
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• W2318552693 doi "https://doi.org/10.1042/bj20110807" @default.
• W2318552693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21696366" @default.
• W2318552693 hasPublicationYear "2011" @default.
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