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• W2318562780 abstract "A new tetraazamacrocyclic bifunctional chelator, TE2A-Bn-NCS, was synthesized in high overall yield from cyclam. An extra functional group (NCS) was introduced to the N-atom of TE2A for specific conjugation with antibody. The Cu complex of TE2A-Bn-NCS showed high kinetic stability in acidic decomplexation and cyclic voltammetry studies. X-ray structure determination of the Cu-TE2A-Bn-NH2 complex confirmed octahedral geometry, in which copper atom is strongly coordinated by four macrocyclic nitrogens in equatorial positions and two carboxylate oxygen atoms occupy the elongated axial positions. Trastuzumab was conjugated with TE2A-Bn-NCS and then radiolabeled with 64Cu quantitatively at room temperature within 10 min. Biodistribution studies showed that the 64Cu-labeled TE2A-Bn-NCS-trastuzumab conjugates maintain high stability in physiological conditions, and NIH3T6.7 tumors were clearly visualized up to 3 days by 64Cu-immuno-positron emission tomography imaging in animal models." @default.
• W2318562780 created "2016-06-24" @default.
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• W2318562780 date "2013-08-12" @default.
• W2318562780 modified "2023-09-27" @default.
• W2318562780 title "New Bifunctional Chelator for ⁶⁴Cu-Immuno-Positron Emission Tomography" @default.
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• W2318562780 doi "https://doi.org/10.1021/bc400192a" @default.
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• W2318562780 hasPublicationYear "2013" @default.
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