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• W2318563985 abstract "ABSTRACT Objective The World Health Organization (WHO) has defined leukocytospermia as > 10 6 WBC/ml of semen. However, the clinical significance of leukocytospermia is currently a subject of controversy. Evidence from several recent studies indicates that leukocytospermia could significantly contribute to oxidative stress and male infertility. Several clinical trials have investigated the efficacy of antibiotic therapy to treat patients with pyospermia in an attempt to improve fertility. Currently, doxycycline is the most common antibiotic used to treat pyospermia though larger trials are needed to demonstrate its efficacy in treating pyospermia. Materials and methods Hundred male partners with semen analysis showing the presence of significant leukocytospermia (WBC > 1 × 10 6 /ml), sterile semen culture and satisfying the inclusion and exclusion criteria were enrolled in the study and given doxycycline 100 mg bd for 14 days. Semen analysis for pus cells and oxidative stress (ROS) measurement was done before and after the treatment. Results Mean pus cell count before and after treatment with doxycycline was 2.28 ± 1.26 × 10 6 /ml and 1.21 ± 0.58 ×10 6 /mL respectively, the effect being statistically significant (p < 0.05). Resolution of leukocytospermia was seen in 61.4% (54/88) cases after doxycycline treatment. Mean oxidative stress (RLU/ sec/million sperms) before and after doxycycline therapy was 79.72 ± 133.9 and 25.44 ± 47.8, the difference being significant (p < 0.05). Conclusion Study results show that treatment with broad spectrum antibiotic like doxycycline leads to significant decrease in the number of pus cells present in semen thereby significantly decreasing the oxidative stress. How to cite this article Aggarwal R. the Effect of Doxycycline on Pus Cells and Oxidative Stress in Male Patients with Leukocytospermia. Int J Infertil Fetal Med 2014;5(3):95-99." @default.
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• W2318563985 date "2014-01-01" @default.
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• W2318563985 title "The Effect of Doxycycline on Pus Cells and Oxidative Stress in Male Patients with Leukocytospermia" @default.
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• W2318563985 doi "https://doi.org/10.5005/jp-journals-10016-1089" @default.
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