Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318590149> ?p ?o ?g. }
- W2318590149 endingPage "245" @default.
- W2318590149 startingPage "237" @default.
- W2318590149 abstract "Doxorubicin (DOX) is an effective anticancer agent, but adverse cardiotoxic effects limit its use. Compounds reducing DOX cardiotoxicity could improve its therapeutic index. This study investigated the protective effects of phenytoin (Phen) for DOX-induced cardiomyopathy. Male Wistar rats were randomized into 5 groups to receive either saline, DOX (2 mg/kg per 48 hours, 6 doses, intraperitoneally) or DOX + Phen (5, 10, or 20 mg/kg/d, starting 4 days before DOX, intraperitoneally). The animals were assessed 24 hours after the last injection. Left ventricular (LV) function and hemodynamic parameters were assessed using transthoracic echocardiography, electrocardiography, and a Millar pressure catheter. Histopathological studies were performed, and the effect of Phen on the cytotoxicity of DOX was evaluated in vitro for the human breast adenocarcinoma cell line. DOX-impaired LV function significantly decreased the LV systolic and diastolic pressures, rate of rise/decrease of LV pressure, ejection fraction, fractional shortening, and contractility index. DOX caused structural changes in myocardial cells. Treatment with Phen decreased DOX-induced toxicity, significantly improved ventricular function, and ameliorated structural changes in the myocardium. Phen also did not interfere with the antitumor effect of DOX. The results confirm the cardioprotective effect of Phen against DOX-induced cardiomyopathy without removing antitumor effect of DOX." @default.
- W2318590149 created "2016-06-24" @default.
- W2318590149 creator A5007209245 @default.
- W2318590149 creator A5024329578 @default.
- W2318590149 creator A5047527554 @default.
- W2318590149 creator A5062413567 @default.
- W2318590149 creator A5085023507 @default.
- W2318590149 creator A5089695349 @default.
- W2318590149 date "2016-03-01" @default.
- W2318590149 modified "2023-10-17" @default.
- W2318590149 title "Cardioprotective Effect of Phenytoin on Doxorubicin-induced Cardiac Toxicity in a Rat Model" @default.
- W2318590149 cites W1757407923 @default.
- W2318590149 cites W1963578253 @default.
- W2318590149 cites W1970327435 @default.
- W2318590149 cites W1971231636 @default.
- W2318590149 cites W1972225026 @default.
- W2318590149 cites W1972589456 @default.
- W2318590149 cites W1973415616 @default.
- W2318590149 cites W1974550609 @default.
- W2318590149 cites W1981860274 @default.
- W2318590149 cites W1986844753 @default.
- W2318590149 cites W1988632535 @default.
- W2318590149 cites W1998318428 @default.
- W2318590149 cites W1998717324 @default.
- W2318590149 cites W1999171637 @default.
- W2318590149 cites W2009845049 @default.
- W2318590149 cites W2011012865 @default.
- W2318590149 cites W2017133942 @default.
- W2318590149 cites W2032191548 @default.
- W2318590149 cites W2042359737 @default.
- W2318590149 cites W2049443309 @default.
- W2318590149 cites W2049727461 @default.
- W2318590149 cites W2049866841 @default.
- W2318590149 cites W2053000187 @default.
- W2318590149 cites W2053420981 @default.
- W2318590149 cites W2075725684 @default.
- W2318590149 cites W2075851548 @default.
- W2318590149 cites W2102785500 @default.
- W2318590149 cites W2111426313 @default.
- W2318590149 cites W2112885253 @default.
- W2318590149 cites W2113017027 @default.
- W2318590149 cites W2122189144 @default.
- W2318590149 cites W2123184457 @default.
- W2318590149 cites W2136891928 @default.
- W2318590149 cites W2163474831 @default.
- W2318590149 cites W2325346963 @default.
- W2318590149 cites W2420818928 @default.
- W2318590149 cites W4236952879 @default.
- W2318590149 cites W791424764 @default.
- W2318590149 doi "https://doi.org/10.1097/fjc.0000000000000339" @default.
- W2318590149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26544684" @default.
- W2318590149 hasPublicationYear "2016" @default.
- W2318590149 type Work @default.
- W2318590149 sameAs 2318590149 @default.
- W2318590149 citedByCount "21" @default.
- W2318590149 countsByYear W23185901492016 @default.
- W2318590149 countsByYear W23185901492017 @default.
- W2318590149 countsByYear W23185901492018 @default.
- W2318590149 countsByYear W23185901492019 @default.
- W2318590149 countsByYear W23185901492020 @default.
- W2318590149 countsByYear W23185901492021 @default.
- W2318590149 countsByYear W23185901492022 @default.
- W2318590149 countsByYear W23185901492023 @default.
- W2318590149 crossrefType "journal-article" @default.
- W2318590149 hasAuthorship W2318590149A5007209245 @default.
- W2318590149 hasAuthorship W2318590149A5024329578 @default.
- W2318590149 hasAuthorship W2318590149A5047527554 @default.
- W2318590149 hasAuthorship W2318590149A5062413567 @default.
- W2318590149 hasAuthorship W2318590149A5085023507 @default.
- W2318590149 hasAuthorship W2318590149A5089695349 @default.
- W2318590149 hasConcept C111566952 @default.
- W2318590149 hasConcept C126322002 @default.
- W2318590149 hasConcept C164705383 @default.
- W2318590149 hasConcept C178853913 @default.
- W2318590149 hasConcept C197934379 @default.
- W2318590149 hasConcept C19831878 @default.
- W2318590149 hasConcept C26635844 @default.
- W2318590149 hasConcept C2776694085 @default.
- W2318590149 hasConcept C2778198053 @default.
- W2318590149 hasConcept C2778233292 @default.
- W2318590149 hasConcept C2778797674 @default.
- W2318590149 hasConcept C2780035454 @default.
- W2318590149 hasConcept C2781303535 @default.
- W2318590149 hasConcept C29730261 @default.
- W2318590149 hasConcept C39133596 @default.
- W2318590149 hasConcept C71924100 @default.
- W2318590149 hasConcept C78085059 @default.
- W2318590149 hasConcept C98274493 @default.
- W2318590149 hasConceptScore W2318590149C111566952 @default.
- W2318590149 hasConceptScore W2318590149C126322002 @default.
- W2318590149 hasConceptScore W2318590149C164705383 @default.
- W2318590149 hasConceptScore W2318590149C178853913 @default.
- W2318590149 hasConceptScore W2318590149C197934379 @default.
- W2318590149 hasConceptScore W2318590149C19831878 @default.
- W2318590149 hasConceptScore W2318590149C26635844 @default.
- W2318590149 hasConceptScore W2318590149C2776694085 @default.
- W2318590149 hasConceptScore W2318590149C2778198053 @default.
- W2318590149 hasConceptScore W2318590149C2778233292 @default.