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- W2318655087 abstract "Objectives: Recent results from the Copenhagen Heart Study have demonstrated a role for non-fasting remnant cholesterol as a causal risk factor for cardiovascular disease (CVD). Evidence in humans, rats and hamsters also show that insulin resistance stimulates overproduction of intestinal derived remnant lipoproteins and may further exacerbate CVD risk. We have recently demonstrated that statins can increase intestinal remnant cholesterol in a rat model of the Metabolic Syndrome (MetS). Here we proposed to evaluate the impact of combining simvastatin (SV) with an intestinal cholesterol absorption inhibitor (ezetimibe [EZ]) on intestinal cholesterol secretion and/or Trans Intestinal Cholesterol Excretion (TICE) in a rodent model of MetS." @default.
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- W2318655087 date "2014-08-01" @default.
- W2318655087 modified "2023-10-16" @default.
- W2318655087 title "Simvastatin and ezetimibe have opposing regulation on intestinal cholesterol absorption and trans intestinal cholesterol excretion (tice) during metabolic syndrome" @default.
- W2318655087 doi "https://doi.org/10.1016/j.atherosclerosis.2014.05.538" @default.
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