Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318707910> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2318707910 endingPage "1164" @default.
- W2318707910 startingPage "1157" @default.
- W2318707910 abstract "Development of stavudine resistance was studied using human immunodeficiency virus type 1 isolates from 13 patients treated with stavudine for 18-22 months. Drug sensitivity testing on 11 of these pre- and posttherapy isolates identified only 2 posttreatment isolates with decreased stavudine sensitivity (ED50s < 4-fold higher than the average pretreatment ED50). Genotypic analysis of all 13 pairs of isolates identified multiple mutations in the reverse transcriptase (RT) gene. However, no genetic basis was identified to account for the observed changes in stavudine susceptibility. A recombinant virus containing the entire RT gene of the posttherapy isolate displaying the greatest resistance remained sensitive to stavudine. Five of the stavudine posttreatment isolates developed resistance (9- to 176-fold) to zidovudine, although the relationship between stavudine treatment and the appearance of zidovudine resistance remains unexplained. Analysis of 10 additional pairs of isolates did not confirm this relationship. The low frequency and modest degree of change in stavudine sensitivity following prolonged treatment is very encouraging." @default.
- W2318707910 created "2016-06-24" @default.
- W2318707910 creator A5004742575 @default.
- W2318707910 creator A5021429609 @default.
- W2318707910 creator A5036262835 @default.
- W2318707910 creator A5049961040 @default.
- W2318707910 creator A5056896082 @default.
- W2318707910 creator A5063877095 @default.
- W2318707910 creator A5077261929 @default.
- W2318707910 creator A5079842687 @default.
- W2318707910 creator A5081584597 @default.
- W2318707910 creator A5088547401 @default.
- W2318707910 date "1994-11-01" @default.
- W2318707910 modified "2023-10-14" @default.
- W2318707910 title "Genotypic And Phenotypic Analysis Of Human Immunodeficiency Virus Type 1 Isolates From Patients On Prolonged Stavudine Therapy" @default.
- W2318707910 doi "https://doi.org/10.1093/infdis/170.5.1157" @default.
- W2318707910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7963708" @default.
- W2318707910 hasPublicationYear "1994" @default.
- W2318707910 type Work @default.
- W2318707910 sameAs 2318707910 @default.
- W2318707910 citedByCount "121" @default.
- W2318707910 countsByYear W23187079102012 @default.
- W2318707910 countsByYear W23187079102013 @default.
- W2318707910 countsByYear W23187079102014 @default.
- W2318707910 countsByYear W23187079102015 @default.
- W2318707910 countsByYear W23187079102020 @default.
- W2318707910 crossrefType "journal-article" @default.
- W2318707910 hasAuthorship W2318707910A5004742575 @default.
- W2318707910 hasAuthorship W2318707910A5021429609 @default.
- W2318707910 hasAuthorship W2318707910A5036262835 @default.
- W2318707910 hasAuthorship W2318707910A5049961040 @default.
- W2318707910 hasAuthorship W2318707910A5056896082 @default.
- W2318707910 hasAuthorship W2318707910A5063877095 @default.
- W2318707910 hasAuthorship W2318707910A5077261929 @default.
- W2318707910 hasAuthorship W2318707910A5079842687 @default.
- W2318707910 hasAuthorship W2318707910A5081584597 @default.
- W2318707910 hasAuthorship W2318707910A5088547401 @default.
- W2318707910 hasConcept C104317684 @default.
- W2318707910 hasConcept C114851261 @default.
- W2318707910 hasConcept C135763542 @default.
- W2318707910 hasConcept C159047783 @default.
- W2318707910 hasConcept C2522874641 @default.
- W2318707910 hasConcept C2776452011 @default.
- W2318707910 hasConcept C2777351918 @default.
- W2318707910 hasConcept C2779889181 @default.
- W2318707910 hasConcept C2780216070 @default.
- W2318707910 hasConcept C2780727368 @default.
- W2318707910 hasConcept C54355233 @default.
- W2318707910 hasConcept C86803240 @default.
- W2318707910 hasConceptScore W2318707910C104317684 @default.
- W2318707910 hasConceptScore W2318707910C114851261 @default.
- W2318707910 hasConceptScore W2318707910C135763542 @default.
- W2318707910 hasConceptScore W2318707910C159047783 @default.
- W2318707910 hasConceptScore W2318707910C2522874641 @default.
- W2318707910 hasConceptScore W2318707910C2776452011 @default.
- W2318707910 hasConceptScore W2318707910C2777351918 @default.
- W2318707910 hasConceptScore W2318707910C2779889181 @default.
- W2318707910 hasConceptScore W2318707910C2780216070 @default.
- W2318707910 hasConceptScore W2318707910C2780727368 @default.
- W2318707910 hasConceptScore W2318707910C54355233 @default.
- W2318707910 hasConceptScore W2318707910C86803240 @default.
- W2318707910 hasIssue "5" @default.
- W2318707910 hasLocation W23187079101 @default.
- W2318707910 hasLocation W23187079102 @default.
- W2318707910 hasOpenAccess W2318707910 @default.
- W2318707910 hasPrimaryLocation W23187079101 @default.
- W2318707910 hasRelatedWork W1984270093 @default.
- W2318707910 hasRelatedWork W2017175082 @default.
- W2318707910 hasRelatedWork W2024099540 @default.
- W2318707910 hasRelatedWork W2054306124 @default.
- W2318707910 hasRelatedWork W2071726907 @default.
- W2318707910 hasRelatedWork W2120231058 @default.
- W2318707910 hasRelatedWork W2177271924 @default.
- W2318707910 hasRelatedWork W2418276897 @default.
- W2318707910 hasRelatedWork W2736657145 @default.
- W2318707910 hasRelatedWork W2298966914 @default.
- W2318707910 hasVolume "170" @default.
- W2318707910 isParatext "false" @default.
- W2318707910 isRetracted "false" @default.
- W2318707910 magId "2318707910" @default.
- W2318707910 workType "article" @default.